C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth factor receptor-bound protein 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141738 GRB7 9606 + 17:39737927-39747291 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309156 GRB7-001 39737927-39747284 protein_coding
  ENST00000394204 GRB7-003 39742252-39747003 protein_coding
  ENST00000394209 GRB7-009 39739967-39746988 protein_coding
  ENST00000394211 GRB7-002 39738337-39747285 protein_coding
  ENST00000445327 GRB7-006 39738771-39747291 protein_coding
  ENST00000461756 GRB7-004 39742934-39743612 retained_intron
  ENST00000473071 GRB7-007 39743272-39744428 retained_intron
  ENST00000485182 GRB7-005 39737949-39743054 retained_intron
  ENST00000577695 GRB7-011 39737927-39742922 protein_coding
  ENST00000578702 GRB7-014 39738353-39744103 processed_transcript
  ENST00000583813 GRB7-012 39737962-39743281 nonsense_mediated_decay
  ENST00000584053 GRB7-013 39740132-39742894 retained_intron
  ENST00000584819 GRB7-008 39738306-39744604 retained_intron
  ENST00000584853 GRB7-010 39737974-39738982 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309156ENST00000394204ENST00000394209ENST00000394211ENST00000445327ENST00000461756ENST00000485182ENST00000578702ENST00000583813ENST00000584053ENST00000584819ENST00000584853
Transcript ID Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309156 N/A N/A 0.499±0.00 N/A N/A N/A 0.189±0.00 N/A N/A 4.406±3.12 4.854±0.82 N/A
ENST00000394204 0.083±0.00 N/A 0.982±0.00 N/A 0.273±0.07 4.341±0.00 N/A N/A 0.014±0.00 0.970±0.00 N/A 0.792±0.00
ENST00000394209 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.414±0.00 0.974±0.00 N/A
ENST00000394211 N/A N/A N/A N/A N/A 11.088±0.00 0.482±0.22 17.318±0.00 N/A 2.325±1.77 6.894±1.74 1.203±0.00
ENST00000445327 N/A N/A N/A N/A N/A N/A 0.299±0.00 0.895±0.00 N/A N/A N/A N/A
ENST00000461756 N/A N/A N/A 1.532±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000485182 N/A 1.134±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000578702 N/A N/A N/A 1.254±0.00 N/A 1.605±0.00 2.576±0.00 N/A N/A 14.667±0.00 N/A N/A
ENST00000583813 N/A N/A N/A 1.408±0.11 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000584053 N/A N/A N/A N/A 0.246±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000584819 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.190±0.00
ENST00000584853 0.097±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0002E0 CIL_0002E0_0001 CGP 17:39728496-39747291
CIL_0002PT CIL_0002PT_0001 CGP 17:39737927-39864188

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003723 IEA RNA binding
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0005925 IDA focal adhesion
GO:0007165 IEA signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0009967 TAS positive regulation of signal transduction
GO:0010494 ISS cytoplasmic stress granule
GO:0017148 ISS negative regulation of translation
GO:0019901 IDA protein kinase binding
GO:0030335 IDA positive regulation of cell migration
GO:0034063 ISS stress granule assembly
GO:0035091 IDA phosphatidylinositol binding
GO:0042802 IPI identical protein binding
GO:0042995 IEA cell projection
GO:0050900 TAS leukocyte migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042726 GRB7 growth factor receptor-bound protein 7 protein_coding Danio_rerio
ENSMUSG00000019312 Grb7 growth factor receptor bound protein 7 protein_coding Mus_musculus

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