C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polo-like kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142731 PLK4 9606 + 4:127880861-127899195 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000270861 PLK4-001 127880861-127899195 protein_coding
  ENST00000503914 PLK4-007 127880899-127883470 retained_intron
  ENST00000507249 PLK4-005 127880929-127898800 protein_coding
  ENST00000507454 PLK4-011 127890997-127892693 retained_intron
  ENST00000508113 PLK4-009 127891171-127898486 protein_coding
  ENST00000510192 PLK4-010 127893200-127898542 retained_intron
  ENST00000510605 PLK4-008 127887334-127891194 retained_intron
  ENST00000511942 PLK4-006 127880893-127883516 processed_transcript
  ENST00000513090 PLK4-003 127880927-127898639 protein_coding
  ENST00000514379 PLK4-002 127881232-127898579 protein_coding
  ENST00000515069 PLK4-004 127880909-127899067 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000270861ENST00000503914ENST00000507249ENST00000507454ENST00000508113ENST00000510192ENST00000510605ENST00000511942ENST00000513090ENST00000514379ENST00000515069
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000270861 N/A N/A N/A N/A N/A 0.337±0.00 0.023±0.00 N/A N/A N/A N/A 0.139±0.00 0.371±0.03 N/A
ENST00000503914 N/A N/A N/A N/A N/A N/A 0.078±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000507249 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.026±0.00 N/A 0.139±0.00 0.251±0.00 N/A
ENST00000507454 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.837±0.00 N/A N/A N/A N/A
ENST00000508113 N/A N/A N/A N/A N/A 0.241±0.00 N/A 0.450±0.00 N/A N/A N/A N/A N/A N/A
ENST00000510192 0.217±0.00 N/A N/A N/A N/A N/A N/A 0.178±0.00 N/A N/A N/A N/A N/A N/A
ENST00000510605 N/A N/A N/A N/A N/A 1.718±0.00 0.121±0.00 0.375±0.00 0.083±0.00 N/A N/A 5.175±0.00 2.557±0.00 15.399±0.00
ENST00000511942 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.673±0.00 N/A N/A N/A N/A
ENST00000513090 0.176±0.00 N/A N/A N/A 0.026±0.00 0.165±0.00 N/A N/A N/A 0.057±0.00 N/A 1.044±0.35 0.302±0.00 6.886±2.15
ENST00000514379 N/A N/A 0.028±0.00 N/A N/A N/A N/A 0.137±0.00 N/A N/A 0.021±0.00 0.373±0.31 N/A 1.900±0.00
ENST00000515069 0.080±0.00 0.437±0.00 N/A 0.506±0.00 0.251±0.03 N/A 0.082±0.00 0.046±0.00 0.199±0.18 0.016±0.00 N/A 1.094±0.78 1.173±0.00 2.441±0.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007AJ CIL_0007AJ_0001 CGP 4:127781821-127899195
CIL_0007AK CIL_0007AK_0001 CGP 4:127880861-127965995

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005730 ISS nucleolus
GO:0005813 IDA centrosome
GO:0005814 IDA centriole
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0007099 IMP centriole replication
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0042802 IEA identical protein binding
GO:0046601 IMP positive regulation of centriole replication
GO:0060707 ISS trophoblast giant cell differentiation
GO:0098535 ISS de novo centriole assembly
GO:0098536 ISS deuterosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004576 plk4 polo-like kinase 4 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000025758 Plk4 polo-like kinase 4 protein_coding Mus_musculus

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