C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polo-like kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025758 Plk4 10090 + 3:40800019-40816883 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026858 Plk4-001 40800019-40816883 protein_coding
  ENSMUST00000166936 Plk4-008 40801463-40802044 retained_intron
  ENSMUST00000167556 Plk4-005 40800254-40816417 protein_coding
  ENSMUST00000168287 Plk4-002 40800054-40816883 protein_coding
  ENSMUST00000168363 Plk4-003 40800028-40808413 retained_intron
  ENSMUST00000169566 Plk4-006 40800781-40805013 protein_coding
  ENSMUST00000170825 Plk4-004 40800050-40806065 protein_coding
  ENSMUST00000171538 Plk4-007 40812738-40816882 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026858ENSMUST00000167556ENSMUST00000168287ENSMUST00000168363ENSMUST00000170825ENSMUST00000171538
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026858 0.365±0.07 0.462±0.16 1.329±0.28 5.136±0.79 N/A 0.644±0.24 N/A 0.328±0.00 7.332±6.91 0.525±0.05 0.047±0.00 2.041±0.95 7.723±4.29 10.484±5.18
ENSMUST00000167556 N/A N/A N/A 0.603±0.00 N/A N/A N/A N/A 2.970±2.83 N/A 0.105±0.06 1.249±0.19 7.886±0.11 7.804±4.67
ENSMUST00000168287 0.393±0.00 0.395±0.07 N/A N/A 0.902±0.00 0.899±0.17 0.140±0.00 0.297±0.00 N/A 0.247±0.00 0.079±0.00 1.680±0.84 N/A N/A
ENSMUST00000168363 N/A 0.267±0.00 N/A 0.663±0.34 0.499±0.39 0.384±0.07 0.045±0.00 0.199±0.06 0.091±0.06 0.395±0.20 0.053±0.03 0.410±0.00 N/A N/A
ENSMUST00000170825 N/A 0.753±0.29 N/A 0.424±0.00 N/A 0.971±0.00 N/A 0.316±0.00 0.250±0.12 N/A 0.074±0.03 N/A 2.477±1.26 7.751±0.00
ENSMUST00000171538 2.078±0.00 0.528±0.07 N/A N/A 1.291±0.00 N/A 0.362±0.10 N/A 0.263±0.14 N/A 0.437±0.00 1.729±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007AJ CIL_0007AJ_0002 CGP 3:40744495-40816883
CIL_0007AK CIL_0007AK_0002 CGP 3:40800019-40846885

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005730 IDA nucleolus
GO:0005813 IEA centrosome
GO:0005814 ISS centriole
GO:0006468 IEA protein phosphorylation
GO:0007099 ISS centriole replication
GO:0042802 IPI identical protein binding
GO:0046601 ISO:ISS positive regulation of centriole replication
GO:0060707 IMP trophoblast giant cell differentiation
GO:0098535 IMP de novo centriole assembly
GO:0098536 IDA deuterosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004576 plk4 polo-like kinase 4 (Drosophila) protein_coding Danio_rerio
ENSG00000142731 PLK4 polo-like kinase 4 protein_coding Homo_sapiens

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