C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: slit homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145147 SLIT2 9606 + 4:20253260-20620561 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000273739 SLIT2-004 20253590-20619286 protein_coding
  ENST00000503823 SLIT2-002 20253260-20619120 protein_coding
  ENST00000503837 SLIT2-003 20253816-20619183 protein_coding
  ENST00000504154 SLIT2-001 20253564-20620557 protein_coding
  ENST00000508541 SLIT2-005 20614863-20619166 retained_intron
  ENST00000508824 SLIT2-006 20254920-20486215 protein_coding
  ENST00000509099 SLIT2-008 20533399-20539566 retained_intron
  ENST00000509394 SLIT2-009 20542494-20552721 processed_transcript
  ENST00000509941 SLIT2-010 20553853-20569264 protein_coding
  ENST00000511508 SLIT2-012 20542619-20568918 protein_coding
  ENST00000512993 SLIT2-011 20598353-20620561 protein_coding
  ENST00000622093 SLIT2-201 20253564-20620559 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000273739ENST00000503823ENST00000503837ENST00000504154ENST00000508541ENST00000512993ENST00000622093
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000273739 N/A N/A N/A N/A 2.533±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000503823 N/A N/A N/A N/A N/A N/A 0.369±0.00 0.806±0.00 0.079±0.00 2.560±0.00 N/A N/A 4.419±0.00 N/A
ENST00000503837 N/A N/A N/A N/A N/A 0.393±0.00 0.186±0.00 N/A N/A 3.146±0.00 0.961±0.00 0.191±0.00 N/A 0.117±0.00
ENST00000504154 1.488±0.00 2.004±0.00 2.663±0.00 1.864±0.67 3.127±1.56 2.557±1.30 0.801±0.18 1.690±0.00 5.215±0.00 7.958±3.40 N/A 0.365±0.16 3.626±1.77 1.767±1.27
ENST00000508541 N/A N/A N/A N/A N/A N/A N/A 0.277±0.00 N/A N/A N/A N/A N/A N/A
ENST00000512993 N/A N/A N/A N/A N/A N/A N/A N/A 0.374±0.00 N/A 1.254±0.00 N/A N/A N/A
ENST00000622093 N/A N/A N/A 1.053±0.00 N/A N/A N/A N/A N/A N/A 0.457±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OP CIL_0002OP_0001 CGP 4:17841199-20620561
CIL_0002OO CIL_0002OO_0001 CGP 4:20253260-20752907

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IEA metanephros development
GO:0001657 IMP ureteric bud development
GO:0001701 IEA in utero embryonic development
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002042 IMP cell migration involved in sprouting angiogenesis
GO:0002689 IDA negative regulation of leukocyte chemotaxis
GO:0005095 IDA GTPase inhibitor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0007409 IEA axonogenesis
GO:0007411 IDA axon guidance
GO:0008045 IDA motor neuron axon guidance
GO:0008201 IDA heparin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010593 IDA negative regulation of lamellipodium assembly
GO:0010596 IDA negative regulation of endothelial cell migration
GO:0010629 IEA negative regulation of gene expression
GO:0014912 IDA negative regulation of smooth muscle cell migration
GO:0016020 NAS membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0021772 IEA olfactory bulb development
GO:0021836 IDA chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 IMP corticospinal neuron axon guidance through spinal cord
GO:0022029 IEA telencephalon cell migration
GO:0030308 IMP negative regulation of cell growth
GO:0030336 IMP negative regulation of cell migration
GO:0030517 IEA negative regulation of axon extension
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0031290 IDA retinal ganglion cell axon guidance
GO:0032870 IEP cellular response to hormone stimulus
GO:0033563 IEA dorsal/ventral axon guidance
GO:0035385 IC Roundabout signaling pathway
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043086 IDA negative regulation of catalytic activity
GO:0043116 IDA negative regulation of vascular permeability
GO:0043237 IDA laminin-1 binding
GO:0043394 IPI proteoglycan binding
GO:0045499 IEA chemorepellent activity
GO:0048495 IPI Roundabout binding
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0048812 IEA neuron projection morphogenesis
GO:0048846 IDA axon extension involved in axon guidance
GO:0050772 TAS positive regulation of axonogenesis
GO:0050919 IDA negative chemotaxis
GO:0050929 IDA induction of negative chemotaxis
GO:0051058 IDA negative regulation of small GTPase mediated signal transduction
GO:0051414 IEP response to cortisol
GO:0060603 IEA mammary gland duct morphogenesis
GO:0060763 IEA mammary duct terminal end bud growth
GO:0061364 IEP apoptotic process involved in luteolysis
GO:0070062 IDA extracellular vesicular exosome
GO:0070100 IMP negative regulation of chemokine-mediated signaling pathway
GO:0071504 IDA cellular response to heparin
GO:0071672 IDA negative regulation of smooth muscle cell chemotaxis
GO:0071676 IDA negative regulation of mononuclear cell migration
GO:0090024 IDA negative regulation of neutrophil chemotaxis
GO:0090027 ISS negative regulation of monocyte chemotaxis
GO:0090260 IDA negative regulation of retinal ganglion cell axon guidance
GO:0090288 IDA negative regulation of cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004246 slit2 slit (Drosophila) homolog 2 protein_coding Danio_rerio
ENSMUSG00000031558 Slit2 slit homolog 2 (Drosophila) protein_coding Mus_musculus

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