C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: slit homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031558 Slit2 10090 + 5:47983155-48306282 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033967 Slit2-003 47983155-48304396 nonsense_mediated_decay
  ENSMUST00000170109 Slit2-001 47984793-48306282 protein_coding
  ENSMUST00000172484 Slit2-005 48231492-48282948 retained_intron
  ENSMUST00000172493 Slit2-014 48242549-48259597 protein_coding
  ENSMUST00000172561 Slit2-015 48256573-48259551 retained_intron
  ENSMUST00000172824 Slit2-013 48223471-48238452 processed_transcript
  ENSMUST00000172998 Slit2-020 47983155-48183157 retained_intron
  ENSMUST00000173107 Slit2-008 47984811-48304522 protein_coding
  ENSMUST00000173303 Slit2-012 48182104-48189530 retained_intron
  ENSMUST00000173646 Slit2-017 48275243-48281799 retained_intron
  ENSMUST00000173671 Slit2-004 48248644-48262665 processed_transcript
  ENSMUST00000173686 Slit2-018 48281778-48302505 nonsense_mediated_decay
  ENSMUST00000173702 Slit2-007 47984811-48304522 protein_coding
  ENSMUST00000173774 Slit2-011 48169193-48192209 processed_transcript
  ENSMUST00000173926 Slit2-010 47984994-48173193 processed_transcript
  ENSMUST00000174061 Slit2-019 47983155-47990332 retained_intron
  ENSMUST00000174313 Slit2-002 47984571-48304956 protein_coding
  ENSMUST00000174421 Slit2-006 47984811-48304522 protein_coding
  ENSMUST00000174487 Slit2-016 48189467-48230121 processed_transcript
  ENSMUST00000174658 Slit2-009 47987842-48189592 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033967ENSMUST00000170109ENSMUST00000172484ENSMUST00000172493ENSMUST00000172998ENSMUST00000173107ENSMUST00000173686ENSMUST00000173702ENSMUST00000173926ENSMUST00000174061ENSMUST00000174313ENSMUST00000174421
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033967 0.380±0.17 0.455±0.39 0.388±0.03 1.783±0.00 1.582±0.47 0.501±0.23 0.443±0.20 1.160±0.50 0.078±0.01 3.073±0.53 0.026±0.01 1.242±0.81 0.387±0.24 0.121±0.06
ENSMUST00000170109 N/A 0.885±0.40 0.790±0.28 N/A 0.819±0.16 N/A 0.245±0.01 0.867±0.19 N/A 2.600±0.00 0.026±0.01 1.705±0.74 0.439±0.28 0.084±0.00
ENSMUST00000172484 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.033±0.00 N/A N/A N/A
ENSMUST00000172493 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.289±0.00 N/A
ENSMUST00000172998 N/A N/A N/A N/A N/A 0.227±0.00 N/A N/A N/A 2.728±0.00 N/A N/A N/A N/A
ENSMUST00000173107 0.124±0.00 N/A N/A N/A N/A N/A 0.325±0.00 N/A 0.055±0.04 1.496±0.00 N/A 0.956±0.00 N/A 0.134±0.00
ENSMUST00000173686 N/A N/A N/A N/A N/A N/A N/A N/A 0.081±0.00 N/A 0.269±0.06 N/A N/A N/A
ENSMUST00000173702 N/A N/A N/A N/A N/A N/A N/A N/A 0.028±0.02 N/A N/A N/A N/A N/A
ENSMUST00000173926 N/A N/A N/A N/A N/A N/A N/A N/A 0.085±0.00 N/A N/A N/A N/A N/A
ENSMUST00000174061 N/A 1.379±0.66 N/A N/A 1.585±0.00 0.636±0.14 0.265±0.00 N/A 0.011±0.00 N/A N/A 1.357±0.36 N/A 0.205±0.00
ENSMUST00000174313 0.253±0.09 0.418±0.00 1.090±0.24 3.534±1.16 1.522±0.84 0.339±0.04 0.285±0.01 1.383±0.32 0.117±0.04 1.755±0.00 0.031±0.01 1.172±0.38 0.406±0.25 0.115±0.03
ENSMUST00000174421 N/A N/A N/A N/A N/A N/A N/A N/A 0.004±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OP CIL_0002OP_0002 CGP 5:45697181-48306282
CIL_0002OO CIL_0002OO_0002 CGP 5:47983155-48388756

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IMP metanephros development
GO:0001657 IEA ureteric bud development
GO:0001701 IMP in utero embryonic development
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002042 IEA cell migration involved in sprouting angiogenesis
GO:0002689 IEA negative regulation of leukocyte chemotaxis
GO:0005095 IEA GTPase inhibitor activity
GO:0005102 TAS receptor binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0007409 IDA axonogenesis
GO:0007411 IGI axon guidance
GO:0008045 IEA motor neuron axon guidance
GO:0008201 IEA heparin binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0009986 IEA cell surface
GO:0010593 IEA negative regulation of lamellipodium assembly
GO:0010596 IEA negative regulation of endothelial cell migration
GO:0010629 IGI negative regulation of gene expression
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016337 IGI single organismal cell-cell adhesion
GO:0021772 IGI olfactory bulb development
GO:0021836 IEA chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 IEA corticospinal neuron axon guidance through spinal cord
GO:0022029 IGI telencephalon cell migration
GO:0030308 IEA negative regulation of cell growth
GO:0030336 IEA negative regulation of cell migration
GO:0030517 IDA negative regulation of axon extension
GO:0030837 IEA negative regulation of actin filament polymerization
GO:0031290 IGI retinal ganglion cell axon guidance
GO:0032870 IEA cellular response to hormone stimulus
GO:0033563 IGI dorsal/ventral axon guidance
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043086 IEA negative regulation of catalytic activity
GO:0043116 IEA negative regulation of vascular permeability
GO:0043237 IEA laminin-1 binding
GO:0043394 IEA proteoglycan binding
GO:0045499 IMP chemorepellent activity
GO:0048495 IEA Roundabout binding
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048812 IGI neuron projection morphogenesis
GO:0048846 IEA axon extension involved in axon guidance
GO:0050919 IMP negative chemotaxis
GO:0050929 IEA induction of negative chemotaxis
GO:0051058 IEA negative regulation of small GTPase mediated signal transduction
GO:0051414 IEA response to cortisol
GO:0060603 IGI mammary gland duct morphogenesis
GO:0060763 IMP mammary duct terminal end bud growth
GO:0061364 IEA apoptotic process involved in luteolysis
GO:0070062 IEA extracellular vesicular exosome
GO:0070100 IEA negative regulation of chemokine-mediated signaling pathway
GO:0071504 IEA cellular response to heparin
GO:0071672 IEA negative regulation of smooth muscle cell chemotaxis
GO:0071676 IEA negative regulation of mononuclear cell migration
GO:0090024 IEA negative regulation of neutrophil chemotaxis
GO:0090260 IEA negative regulation of retinal ganglion cell axon guidance
GO:0090288 IEA negative regulation of cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004246 slit2 slit (Drosophila) homolog 2 protein_coding Danio_rerio
ENSG00000145147 SLIT2 slit homolog 2 (Drosophila) protein_coding Homo_sapiens

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