C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: slit homolog 2 (Drosophila)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000504154 SLIT2-001 ENSG00000145147 9606 + 4:20253564-20620557 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000504154
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000504154 1.488±0.00 2.004±0.00 2.663±0.00 1.864±0.67 3.127±1.56 2.557±1.30 0.801±0.18 1.690±0.00 5.215±0.00 7.958±3.40 0.365±0.16 3.626±1.77 1.767±1.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OP CIL_0002OP_0001 CGP 4:17841199-20620561
CIL_0002OO CIL_0002OO_0001 CGP 4:20253260-20752907

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001656 IEA metanephros development
GO:0001657 IMP ureteric bud development
GO:0001701 IEA in utero embryonic development
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002042 IMP cell migration involved in sprouting angiogenesis
GO:0002689 IDA negative regulation of leukocyte chemotaxis
GO:0005095 IDA GTPase inhibitor activity
GO:0005509 NAS:IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0007409 IEA axonogenesis
GO:0007411 IDA axon guidance
GO:0008045 IDA motor neuron axon guidance
GO:0008201 IDA heparin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010593 IDA negative regulation of lamellipodium assembly
GO:0010596 IDA negative regulation of endothelial cell migration
GO:0010629 IEA negative regulation of gene expression
GO:0014912 IDA negative regulation of smooth muscle cell migration
GO:0016020 NAS membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0021772 IEA olfactory bulb development
GO:0021836 IDA chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 IMP corticospinal neuron axon guidance through spinal cord
GO:0022029 IEA telencephalon cell migration
GO:0030308 IMP negative regulation of cell growth
GO:0030336 IMP negative regulation of cell migration
GO:0030517 IEA negative regulation of axon extension
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0031290 IDA retinal ganglion cell axon guidance
GO:0032870 IEP cellular response to hormone stimulus
GO:0033563 IEA dorsal/ventral axon guidance
GO:0035385 IC Roundabout signaling pathway
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043086 IDA negative regulation of catalytic activity
GO:0043116 IDA negative regulation of vascular permeability
GO:0043237 IDA laminin-1 binding
GO:0043394 IPI proteoglycan binding
GO:0045499 IEA chemorepellent activity
GO:0048495 IPI Roundabout binding
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0048812 IEA neuron projection morphogenesis
GO:0048846 IDA axon extension involved in axon guidance
GO:0050772 TAS positive regulation of axonogenesis
GO:0050919 IDA negative chemotaxis
GO:0050929 IDA induction of negative chemotaxis
GO:0051058 IDA negative regulation of small GTPase mediated signal transduction
GO:0051414 IEP response to cortisol
GO:0060603 IEA mammary gland duct morphogenesis
GO:0060763 IEA mammary duct terminal end bud growth
GO:0061364 IEP apoptotic process involved in luteolysis
GO:0070062 IDA extracellular vesicular exosome
GO:0070100 IMP negative regulation of chemokine-mediated signaling pathway
GO:0071504 IDA cellular response to heparin
GO:0071672 IDA negative regulation of smooth muscle cell chemotaxis
GO:0071676 IDA negative regulation of mononuclear cell migration
GO:0090024 IDA negative regulation of neutrophil chemotaxis
GO:0090027 ISS negative regulation of monocyte chemotaxis
GO:0090260 IDA negative regulation of retinal ganglion cell axon guidance
GO:0090288 IDA negative regulation of cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000170109 Slit2-001 protein_coding Mus_musculus 0 6381
ENSMUST00000173107 Slit2-008 protein_coding Mus_musculus 0 6067
ENSMUST00000174313 Slit2-002 protein_coding Mus_musculus 0 6043
ENSMUST00000173702 Slit2-007 protein_coding Mus_musculus 0 6011
ENSMUST00000174421 Slit2-006 protein_coding Mus_musculus 0 5882
ENSMUST00000033967 Slit2-003 nonsense_mediated_decay Mus_musculus 0 3206
ENSMUST00000174487 Slit2-016 processed_transcript Mus_musculus 0 1336
ENSMUST00000172484 Slit2-005 retained_intron Mus_musculus 0 1219
ENSMUST00000172824 Slit2-013 processed_transcript Mus_musculus 0 946
ENSMUST00000173686 Slit2-018 nonsense_mediated_decay Mus_musculus 0 902
ENSMUST00000173671 Slit2-004 processed_transcript Mus_musculus 0 686
ENSMUST00000172998 Slit2-020 retained_intron Mus_musculus 0 680
ENSMUST00000172493 Slit2-014 protein_coding Mus_musculus 0 619
ENSMUST00000173926 Slit2-010 processed_transcript Mus_musculus 0 586
ENSMUST00000173774 Slit2-011 processed_transcript Mus_musculus 0 540
ENSMUST00000174658 Slit2-009 nonsense_mediated_decay Mus_musculus 0 420
ENSMUST00000174061 Slit2-019 retained_intron Mus_musculus 0 388
ENSMUST00000173303 Slit2-012 retained_intron Mus_musculus 0 333

Loading