C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific demethylase 6A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147050 KDM6A 9606 + X:44873177-45112602 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000377967 KDM6A-001 44873511-45112602 protein_coding
  ENST00000382899 KDM6A-201 44873177-45112598 protein_coding
  ENST00000414389 KDM6A-002 45059346-45112602 protein_coding
  ENST00000431196 KDM6A-008 45090817-45111662 protein_coding
  ENST00000433797 KDM6A-003 45060057-45112602 protein_coding
  ENST00000451692 KDM6A-005 45059282-45063676 protein_coding
  ENST00000475233 KDM6A-004 44873715-45020730 processed_transcript
  ENST00000479423 KDM6A-009 45106940-45110249 processed_transcript
  ENST00000484732 KDM6A-007 45082586-45086225 processed_transcript
  ENST00000485072 KDM6A-006 45082398-45083523 processed_transcript
  ENST00000536777 KDM6A-202 44873177-45112598 protein_coding
  ENST00000543216 KDM6A-203 44873177-45112598 protein_coding
  ENST00000611820 KDM6A-204 44873177-45112598 protein_coding
  ENST00000621147 KDM6A-205 44873552-45111411 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000377967ENST00000382899ENST00000414389ENST00000431196ENST00000433797ENST00000479423ENST00000536777ENST00000543216ENST00000611820ENST00000621147
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000377967 N/A 0.349±0.00 0.769±0.00 0.370±0.00 0.973±0.00 0.567±0.11 0.586±0.00 N/A 0.564±0.00 2.128±0.00 1.163±0.00 1.165±0.40 0.725±0.21 1.111±0.53
ENST00000382899 0.684±0.00 N/A N/A N/A N/A N/A N/A N/A 0.569±0.00 1.469±0.00 N/A 1.085±0.18 N/A 0.681±0.00
ENST00000414389 1.003±0.00 0.911±0.00 0.937±0.00 0.646±0.00 1.993±0.48 1.055±0.18 N/A 2.038±0.00 1.092±0.00 0.824±0.00 0.424±0.00 1.872±0.53 N/A N/A
ENST00000431196 N/A 3.964±0.00 N/A N/A 4.466±0.00 2.965±0.00 N/A 5.043±0.00 1.441±0.00 N/A N/A 4.910±0.00 1.556±0.00 4.686±0.00
ENST00000433797 N/A N/A N/A 0.418±0.00 0.655±0.00 N/A 0.393±0.00 1.256±0.00 0.734±0.00 N/A N/A 1.238±0.00 0.711±0.11 1.398±0.32
ENST00000479423 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.717±0.00
ENST00000536777 N/A N/A N/A 0.981±0.00 N/A N/A N/A N/A 0.175±0.00 N/A 0.875±0.24 N/A 0.288±0.00 N/A
ENST00000543216 N/A 0.461±0.00 N/A N/A N/A N/A 0.547±0.00 N/A N/A N/A N/A 0.633±0.00 0.426±0.00 N/A
ENST00000611820 N/A N/A N/A N/A 1.154±0.00 N/A N/A N/A 0.236±0.00 N/A N/A N/A N/A 1.055±0.00
ENST00000621147 1.189±0.00 N/A N/A N/A N/A N/A 0.606±0.00 0.707±0.00 N/A N/A 1.598±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QA CIL_0005QA_0001 CGP X:44844004-45112602
CIL_0003JA CIL_0003JA_0002 CGP X:44873177-45200901

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001701 IEA in utero embryonic development
GO:0001843 IEA neural tube closure
GO:0003007 IEA heart morphogenesis
GO:0003016 IEA respiratory system process
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0007507 IEA heart development
GO:0010468 IEA regulation of gene expression
GO:0021915 IEA neural tube development
GO:0032525 IEA somite rostral/caudal axis specification
GO:0035097 IDA histone methyltransferase complex
GO:0035264 IEA multicellular organism growth
GO:0042802 IEA identical protein binding
GO:0046872 IEA metal ion binding
GO:0048333 IEA mesodermal cell differentiation
GO:0048568 IEA embryonic organ development
GO:0048570 IEA notochord morphogenesis
GO:0051213 IEA dioxygenase activity
GO:0051568 ISS histone H3-K4 methylation
GO:0055114 IEA oxidation-reduction process
GO:0060070 IEA canonical Wnt signaling pathway
GO:0071557 IEA histone H3-K27 demethylation
GO:0071558 IEA histone demethylase activity (H3-K27 specific)
GO:0072358 IEA cardiovascular system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059794 kdm6al lysine (K)-specific demethylase 6A, like protein_coding Danio_rerio
ENSDARG00000061759 kdm6a lysine (K)-specific demethylase 6A protein_coding Danio_rerio
ENSMUSG00000037369 Kdm6a lysine (K)-specific demethylase 6A protein_coding Mus_musculus

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