C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: high mobility group AT-hook 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149948 HMGA2 9606 + 12:65824131-65966295 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354636 HMGA2-008 65824460-65915527 protein_coding
  ENST00000393577 HMGA2-013 65825123-65952536 protein_coding
  ENST00000393578 HMGA2-005 65824460-65843523 protein_coding
  ENST00000403681 HMGA2-001 65824131-65966295 protein_coding
  ENST00000425208 HMGA2-006 65824460-65882126 protein_coding
  ENST00000536545 HMGA2-003 65824460-65915447 protein_coding
  ENST00000537275 HMGA2-004 65824460-65842917 nonsense_mediated_decay
  ENST00000537429 HMGA2-007 65824460-65881890 nonsense_mediated_decay
  ENST00000539662 HMGA2-012 65828001-65963410 nonsense_mediated_decay
  ENST00000541363 HMGA2-011 65824898-65958854 protein_coding
  ENST00000545998 HMGA2-009 65824811-65829013 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000393578ENST00000403681ENST00000425208ENST00000536545ENST00000541363ENST00000545998
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000393578 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.041±0.00 0.838±0.00
ENST00000403681 0.025±0.00 N/A N/A 0.793±0.00 0.239±0.00 N/A 0.100±0.00 N/A 0.071±0.00 4.059±4.22 0.046±0.03 0.665±0.27
ENST00000425208 N/A N/A N/A N/A N/A N/A N/A 0.067±0.00 N/A N/A N/A N/A
ENST00000536545 0.132±0.00 N/A 0.186±0.00 N/A N/A 0.038±0.00 N/A 0.024±0.00 N/A N/A N/A 0.748±0.00
ENST00000541363 0.026±0.00 N/A N/A 0.013±0.00 0.358±0.00 0.009±0.00 N/A N/A 0.008±0.00 N/A N/A N/A
ENST00000545998 N/A 0.176±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088X CIL_00088X_0001 VISTA 12:65441147-66043028

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000228 ISS nuclear chromosome
GO:0000737 IDA DNA catabolic process, endonucleolytic
GO:0000785 IEA chromatin
GO:0000975 IDA regulatory region DNA binding
GO:0000989 IDA transcription factor binding transcription factor activity
GO:0001047 IDA core promoter binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001837 IMP epithelial to mesenchymal transition
GO:0002062 IDA chondrocyte differentiation
GO:0003131 IMP mesodermal-endodermal cell signaling
GO:0003677 NAS:IEA DNA binding
GO:0003680 IDA AT DNA binding
GO:0003906 IDA DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677 IDA DNA-dependent protein kinase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006284 IDA base-excision repair
GO:0006325 TAS chromatin organization
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0007067 IEA mitotic nuclear division
GO:0007095 IDA mitotic G2 DNA damage checkpoint
GO:0007165 IEA signal transduction
GO:0007275 TAS multicellular organismal development
GO:0007283 IEA spermatogenesis
GO:0008134 IPI transcription factor binding
GO:0008283 IEA cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0008301 IMP DNA binding, bending
GO:0008584 IEA male gonad development
GO:0009615 IEP response to virus
GO:0010564 IDA regulation of cell cycle process
GO:0010628 IDA positive regulation of gene expression
GO:0019899 IEA enzyme binding
GO:0021846 IEA cell proliferation in forebrain
GO:0021983 IEA pituitary gland development
GO:0030261 IEA chromosome condensation
GO:0030325 IEA adrenal gland development
GO:0031052 IDA chromosome breakage
GO:0031492 IDA nucleosomal DNA binding
GO:0031507 IDA heterochromatin assembly
GO:0032993 IDA protein-DNA complex
GO:0033144 IEA negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0035019 IEA somatic stem cell maintenance
GO:0035497 IDA cAMP response element binding
GO:0035500 IDA MH2 domain binding
GO:0035501 IDA MH1 domain binding
GO:0035978 IDA histone H2A-S139 phosphorylation
GO:0035985 IDA senescence-associated heterochromatin focus
GO:0035986 IDA senescence-associated heterochromatin focus assembly
GO:0035987 IMP endodermal cell differentiation
GO:0035988 IDA chondrocyte proliferation
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042769 IDA DNA damage response, detection of DNA damage
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0043922 IDA negative regulation by host of viral transcription
GO:0045444 IMP fat cell differentiation
GO:0045869 IDA negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046426 IEA negative regulation of JAK-STAT cascade
GO:0048333 IMP mesodermal cell differentiation
GO:0048712 IEA negative regulation of astrocyte differentiation
GO:0048762 IMP mesenchymal cell differentiation
GO:0048863 IEP stem cell differentiation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051575 IDA 5'-deoxyribose-5-phosphate lyase activity
GO:0060123 IEA regulation of growth hormone secretion
GO:0060612 IEA adipose tissue development
GO:0060613 IEA fat pad development
GO:0070742 IMP C2H2 zinc finger domain binding
GO:0071141 IDA SMAD protein complex
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0090276 IEA regulation of peptide hormone secretion
GO:0090402 IDA oncogene-induced cell senescence
GO:2000036 IMP regulation of stem cell maintenance
GO:2000648 IMP positive regulation of stem cell proliferation
GO:2000679 IDA positive regulation of transcription regulatory region DNA binding
GO:2000685 IDA positive regulation of cellular response to X-ray
GO:2000774 IMP positive regulation of cellular senescence
GO:2001022 IDA positive regulation of response to DNA damage stimulus
GO:2001033 IDA negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038 IDA regulation of cellular response to drug

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069912 hmga2 high mobility group AT-hook 2 protein_coding Danio_rerio
ENSMUSG00000056758 Hmga2 high mobility group AT-hook 2 protein_coding Mus_musculus

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