C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151067 CACNA1C 9606 + 12:1970786-2697950 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000327702 CACNA1C-023 2053563-2691293 protein_coding
  ENST00000335762 CACNA1C-015 2053298-2691410 protein_coding
  ENST00000344100 CACNA1C-021 2053563-2691293 protein_coding
  ENST00000347598 CACNA1C-017 2053563-2691293 protein_coding
  ENST00000399591 CACNA1C-008 2053563-2691293 protein_coding
  ENST00000399595 CACNA1C-002 2053563-2691293 protein_coding
  ENST00000399597 CACNA1C-005 2053563-2691293 protein_coding
  ENST00000399601 CACNA1C-020 2053563-2691293 protein_coding
  ENST00000399603 CACNA1C-011 2053563-2692159 protein_coding
  ENST00000399606 CACNA1C-019 2053563-2691293 protein_coding
  ENST00000399617 CACNA1C-013 2053563-2692159 protein_coding
  ENST00000399621 CACNA1C-006 2053563-2691293 protein_coding
  ENST00000399629 CACNA1C-022 2053563-2691293 protein_coding
  ENST00000399634 CACNA1C-012 2053563-2692159 protein_coding
  ENST00000399637 CACNA1C-007 2053563-2691293 protein_coding
  ENST00000399638 CACNA1C-004 2053563-2691293 protein_coding
  ENST00000399641 CACNA1C-010 2053563-2691293 protein_coding
  ENST00000399644 CACNA1C-003 2053563-2691293 protein_coding
  ENST00000399649 CACNA1C-024 2053563-2691293 protein_coding
  ENST00000399655 CACNA1C-001 2053298-2697950 protein_coding
  ENST00000402845 CACNA1C-032 2053563-2691293 protein_coding
  ENST00000406454 CACNA1C-031 2053563-2692159 protein_coding
  ENST00000465278 CACNA1C-016 2582884-2596206 protein_coding
  ENST00000465934 CACNA1C-025 2666616-2677813 retained_intron
  ENST00000480911 CACNA1C-018 2053538-2614971 protein_coding
  ENST00000483136 CACNA1C-027 2641458-2651747 processed_transcript
  ENST00000491104 CACNA1C-014 2504436-2566582 processed_transcript
  ENST00000492150 CACNA1C-029 2651063-2655193 retained_intron
  ENST00000496818 CACNA1C-026 2607880-2610699 protein_coding
  ENST00000543114 CACNA1C-034 1970786-2115384 protein_coding
  ENST00000613940 CACNA1C-201 2448976-2697949 protein_coding
  ENST00000615303 CACNA1C-202 2448976-2697949 protein_coding
  ENST00000615400 CACNA1C-203 2448976-2697949 protein_coding
  ENST00000616390 CACNA1C-036 2641467-2691267 protein_coding
  ENST00000620878 CACNA1C-204 2448976-2697949 protein_coding
  ENST00000621625 CACNA1C-205 2448976-2697949 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335762ENST00000399591ENST00000399597ENST00000399603ENST00000399634ENST00000399641ENST00000399649ENST00000399655ENST00000465278ENST00000465934ENST00000480911ENST00000543114ENST00000615400ENST00000616390ENST00000620878ENST00000621625
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335762 0.469±0.00 N/A 0.256±0.00 N/A 0.427±0.00 0.604±0.00 N/A N/A N/A 0.844±0.00 N/A 0.611±0.29 0.485±0.13 1.067±0.00
ENST00000399591 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.058±0.00 N/A N/A N/A
ENST00000399597 N/A N/A N/A N/A 1.031±0.00 N/A N/A N/A 2.089±0.00 N/A N/A N/A N/A N/A
ENST00000399603 0.424±0.00 N/A N/A N/A 0.422±0.00 2.014±0.00 4.756±0.00 N/A N/A N/A N/A 0.312±0.00 0.702±0.21 0.772±0.00
ENST00000399634 N/A N/A N/A N/A N/A N/A 4.919±0.00 0.405±0.00 N/A 1.183±0.00 N/A 0.672±0.00 N/A N/A
ENST00000399641 N/A N/A N/A N/A N/A N/A 3.014±0.00 N/A N/A N/A 0.060±0.00 N/A N/A N/A
ENST00000399649 N/A N/A N/A N/A N/A N/A N/A N/A 0.039±0.00 N/A N/A N/A N/A N/A
ENST00000399655 N/A 0.739±0.00 N/A 0.483±0.00 0.896±0.00 0.494±0.00 0.676±0.00 N/A 1.314±0.00 N/A N/A N/A 0.138±0.00 0.435±0.00
ENST00000465278 N/A N/A N/A N/A N/A 3.475±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000465934 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.892±0.00 N/A
ENST00000480911 N/A N/A N/A N/A 1.067±0.00 N/A 1.137±0.00 0.111±0.00 1.533±0.00 N/A N/A N/A N/A N/A
ENST00000543114 N/A N/A N/A N/A N/A N/A 25.833±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000615400 N/A N/A N/A 0.678±0.00 N/A N/A N/A N/A N/A 0.290±0.00 N/A N/A 0.156±0.00 N/A
ENST00000616390 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.430±0.38 0.884±0.00 3.077±0.86
ENST00000620878 N/A N/A N/A 0.356±0.00 N/A 0.802±0.00 N/A N/A N/A N/A 0.115±0.00 N/A N/A N/A
ENST00000621625 N/A N/A N/A N/A 0.151±0.00 N/A 2.084±0.00 N/A N/A N/A N/A N/A N/A 0.543±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003XI CIL_0003XI_0002 CGP 12:1820267-2004535
CIL_0003XH CIL_0003XH_0002 CGP 12:1946054-2697950

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002095 IEA caveolar macromolecular signaling complex
GO:0005216 IEA ion channel activity
GO:0005245 IEA voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005516 IPI calmodulin binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005891 IEA voltage-gated calcium channel complex
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006939 IEA smooth muscle contraction
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0007268 IEA synaptic transmission
GO:0007411 TAS axon guidance
GO:0007628 IEA adult walking behavior
GO:0008217 IEA regulation of blood pressure
GO:0008331 IBA high voltage-gated calcium channel activity
GO:0008542 IEA visual learning
GO:0010881 TAS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014069 IDA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IDA integral component of membrane
GO:0017156 IEA calcium ion-dependent exocytosis
GO:0019229 IEA regulation of vasoconstriction
GO:0019899 IEA enzyme binding
GO:0030018 ISS Z disc
GO:0030073 IEA insulin secretion
GO:0030252 IEA growth hormone secretion
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035585 TAS calcium-mediated signaling using extracellular calcium source
GO:0042593 IEA glucose homeostasis
GO:0043025 IEA neuronal cell body
GO:0043198 IEA dendritic shaft
GO:0044281 TAS small molecule metabolic process
GO:0046620 IEA regulation of organ growth
GO:0046872 IEA metal ion binding
GO:0050796 TAS regulation of insulin secretion
GO:0051393 IPI alpha-actinin binding
GO:0055085 IEA transmembrane transport
GO:0060083 IEA smooth muscle contraction involved in micturition
GO:0060402 TAS calcium ion transport into cytosol
GO:0070509 IBA calcium ion import
GO:0070588 IEA calcium ion transmembrane transport
GO:0086010 IBA membrane depolarization during action potential
GO:0086064 TAS cell communication by electrical coupling involved in cardiac conduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008398 cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit protein_coding Danio_rerio
ENSMUSG00000051331 Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit protein_coding Mus_musculus

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