C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: calcium channel, voltage-dependent, L type, alpha 1C subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000399591 CACNA1C-008 ENSG00000151067 9606 + 12:2053563-2691293 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; MuscleENST00000399591
Transcript ID Muscle
ENST00000399591 0.058±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003XI CIL_0003XI_0002 CGP 12:1820267-2004535
CIL_0003XH CIL_0003XH_0002 CGP 12:1946054-2697950

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005245 IDA voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005516 IPI calmodulin binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005891 IDA voltage-gated calcium channel complex
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0007411 TAS axon guidance
GO:0008331 IBA high voltage-gated calcium channel activity
GO:0010881 TAS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014069 IDA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IDA integral component of membrane
GO:0030018 ISS Z disc
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035585 TAS calcium-mediated signaling using extracellular calcium source
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0050796 TAS regulation of insulin secretion
GO:0051393 IPI alpha-actinin binding
GO:0055085 IEA transmembrane transport
GO:0060402 TAS calcium ion transport into cytosol
GO:0070509 IBA calcium ion import
GO:0070588 IEA calcium ion transmembrane transport
GO:0086010 IBA membrane depolarization during action potential
GO:0086064 TAS cell communication by electrical coupling involved in cardiac conduction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000188865 Cacna1c-020 protein_coding Mus_musculus 0 5369
ENSMUST00000189520 Cacna1c-017 protein_coding Mus_musculus 0 5219
ENSMUST00000188078 Cacna1c-015 protein_coding Mus_musculus 0 5219
ENSMUST00000112790 Cacna1c-005 protein_coding Mus_musculus 0 5203
ENSMUST00000189389 Cacna1c-016 protein_coding Mus_musculus 0 5086
ENSMUST00000075591 Cacna1c-024 protein_coding Mus_musculus 0 5053
ENSMUST00000078320 Cacna1c-004 protein_coding Mus_musculus 0 5053
ENSMUST00000187940 Cacna1c-002 protein_coding Mus_musculus 0 5000
ENSMUST00000186889 Cacna1c-001 protein_coding Mus_musculus 0 4983
ENSMUST00000187474 Cacna1c-008 protein_coding Mus_musculus 0 4850
ENSMUST00000188106 Cacna1c-011 protein_coding Mus_musculus 0 4349
ENSMUST00000185345 Cacna1c-019 protein_coding Mus_musculus 0 3688
ENSMUST00000187317 Cacna1c-018 protein_coding Mus_musculus 0 3688
ENSMUST00000112793 Cacna1c-010 protein_coding Mus_musculus 0 3567
ENSMUST00000187386 Cacna1c-006 protein_coding Mus_musculus 0 3434
ENSMUST00000188522 Cacna1c-014 protein_coding Mus_musculus 0 3434
ENSMUST00000190285 Cacna1c-007 protein_coding Mus_musculus 0 3284
ENSMUST00000112825 Cacna1c-201 protein_coding Mus_musculus 0 2490
ENSMUST00000188181 Cacna1c-012 processed_transcript Mus_musculus 0 2490
ENSDART00000028856 cacna1c-201 protein_coding Danio_rerio 0 2281
ENSDART00000132909 cacna1c-001 protein_coding Danio_rerio 0 2206
ENSMUST00000161865 Cacna1s-003 protein_coding Mus_musculus 0 1286
ENSMUST00000112068 Cacna1s-001 protein_coding Mus_musculus 0 1286
ENSDART00000089956 cacna1da-201 protein_coding Danio_rerio 0 1243
ENSDART00000058276 cacna1da-001 protein_coding Danio_rerio 0 1243
ENSMUST00000112250 Cacna1d-202 protein_coding Mus_musculus 0 1107
ENSMUST00000112249 Cacna1d-201 protein_coding Mus_musculus 0 1107
ENSDART00000100118 cacna1da-202 protein_coding Danio_rerio 0 784
ENSMUST00000112064 Cacna1s-201 protein_coding Mus_musculus 0 713
ENSMUST00000160641 Cacna1s-002 protein_coding Mus_musculus 0 713
ENSMUST00000189057 Cacna1c-003 processed_transcript Mus_musculus 0 534
ENSDART00000065375 cacna1db-201 protein_coding Danio_rerio 0 492
ENSMUST00000187849 Cacna1c-023 processed_transcript Mus_musculus 0 472
ENSMUST00000191196 Cacna1c-021 processed_transcript Mus_musculus 0 435
ENSDART00000062406 cacna1sb-001 protein_coding Danio_rerio 0 364
ENSMUST00000155090 Cacna1f-003 nonsense_mediated_decay Mus_musculus 0 1031
ENSMUST00000115726 Cacna1f-001 protein_coding Mus_musculus 0 1031
ENSMUST00000115725 Cacna1f-002 protein_coding Mus_musculus 0 1094
ENSMUST00000141634 Cacna1f-004 retained_intron Mus_musculus 0 1031
ENSDART00000105895 cacna1sa-001 protein_coding Danio_rerio 0 383

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