C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000051331 Cacna1c 10090 - 6:118587240-119196418 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000075591 Cacna1c-024 118592942-119108189 protein_coding
  ENSMUST00000078320 Cacna1c-004 118592464-119108189 protein_coding
  ENSMUST00000112790 Cacna1c-005 118592942-119108236 protein_coding
  ENSMUST00000112793 Cacna1c-010 118593892-119107975 protein_coding
  ENSMUST00000112825 Cacna1c-201 118592319-118757974 protein_coding
  ENSMUST00000185345 Cacna1c-019 118593793-119107975 protein_coding
  ENSMUST00000186889 Cacna1c-001 118587240-119196231 protein_coding
  ENSMUST00000187317 Cacna1c-018 118593793-119107975 protein_coding
  ENSMUST00000187386 Cacna1c-006 118593799-119080007 protein_coding
  ENSMUST00000187474 Cacna1c-008 118593647-119196387 protein_coding
  ENSMUST00000187849 Cacna1c-023 118614026-118627946 processed_transcript
  ENSMUST00000187940 Cacna1c-002 118593082-119196418 protein_coding
  ENSMUST00000188078 Cacna1c-015 118593793-119107975 protein_coding
  ENSMUST00000188106 Cacna1c-011 118593892-119107975 protein_coding
  ENSMUST00000188181 Cacna1c-012 118592319-118757974 processed_transcript
  ENSMUST00000188522 Cacna1c-014 118593647-119108573 protein_coding
  ENSMUST00000188865 Cacna1c-020 118593793-119107975 protein_coding
  ENSMUST00000189057 Cacna1c-003 118946163-119196409 processed_transcript
  ENSMUST00000189389 Cacna1c-016 118593793-119107975 protein_coding
  ENSMUST00000189520 Cacna1c-017 118593793-119107975 protein_coding
  ENSMUST00000189930 Cacna1c-013 118702217-118707147 retained_intron
  ENSMUST00000190285 Cacna1c-007 118593892-119196231 protein_coding
  ENSMUST00000191196 Cacna1c-021 118592304-118595426 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000075591ENSMUST00000078320ENSMUST00000112790ENSMUST00000112825ENSMUST00000185345ENSMUST00000186889ENSMUST00000187386ENSMUST00000187474ENSMUST00000187940ENSMUST00000188078ENSMUST00000188106ENSMUST00000188522ENSMUST00000188865ENSMUST00000189389ENSMUST00000189520ENSMUST00000190285ENSMUST00000191196
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000075591 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.160±0.00
ENSMUST00000078320 1.145±0.87 N/A N/A 1.507±0.19 N/A 0.557±0.04 5.512±0.31 0.080±0.02 N/A 1.599±0.19 0.076±0.00 1.257±0.30 0.061±0.04 0.176±0.08
ENSMUST00000112790 2.091±0.00 N/A N/A N/A N/A N/A N/A 0.138±0.00 N/A 1.717±0.14 N/A N/A N/A 0.192±0.00
ENSMUST00000112825 N/A N/A N/A N/A 0.195±0.00 N/A N/A N/A 0.113±0.05 N/A 0.078±0.00 N/A N/A N/A
ENSMUST00000185345 N/A 4.813±0.00 N/A N/A 0.901±0.00 1.050±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000186889 1.454±0.00 N/A 4.927±1.86 2.057±0.70 N/A 0.633±0.00 N/A N/A 0.023±0.01 N/A N/A 1.194±0.28 0.164±0.11 0.146±0.02
ENSMUST00000187386 N/A N/A N/A N/A N/A N/A N/A 0.088±0.00 0.046±0.02 N/A N/A N/A N/A 0.243±0.13
ENSMUST00000187474 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.079±0.03 N/A
ENSMUST00000187940 N/A N/A N/A N/A 0.274±0.00 N/A 9.886±1.05 N/A 0.055±0.01 N/A N/A N/A N/A N/A
ENSMUST00000188078 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.456±0.00 N/A 0.021±0.00
ENSMUST00000188106 N/A N/A N/A N/A N/A N/A N/A N/A 0.031±0.03 1.275±0.00 0.159±0.01 N/A 0.210±0.00 0.289±0.00
ENSMUST00000188522 1.911±1.75 5.277±1.51 2.195±0.58 1.095±0.00 0.443±0.17 1.099±0.32 N/A 0.173±0.03 N/A 2.128±0.31 N/A 2.162±0.72 0.254±0.17 0.150±0.00
ENSMUST00000188865 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.329±0.00 0.183±0.00 N/A
ENSMUST00000189389 N/A N/A N/A N/A 0.835±0.00 1.153±0.12 N/A N/A N/A N/A N/A 1.062±0.00 N/A N/A
ENSMUST00000189520 N/A 3.142±0.20 N/A N/A 0.190±0.00 0.445±0.00 N/A 0.127±0.00 N/A 1.530±0.03 N/A 2.068±0.00 N/A 0.141±0.00
ENSMUST00000190285 N/A N/A N/A N/A N/A N/A N/A 0.062±0.00 N/A N/A N/A N/A 0.137±0.00 N/A
ENSMUST00000191196 N/A 14.071±3.62 N/A N/A N/A 1.577±0.00 N/A N/A N/A N/A N/A 4.374±0.00 0.139±0.06 0.120±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002095 IDA caveolar macromolecular signaling complex
GO:0005245 TAS voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005891 TAS voltage-gated calcium channel complex
GO:0006816 IMP calcium ion transport
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006939 IMP smooth muscle contraction
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007268 IMP synaptic transmission
GO:0007628 IGI adult walking behavior
GO:0008217 IMP regulation of blood pressure
GO:0008331 IBA high voltage-gated calcium channel activity
GO:0008542 IMP visual learning
GO:0014069 IEA postsynaptic density
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0017156 IMP calcium ion-dependent exocytosis
GO:0019229 IMP regulation of vasoconstriction
GO:0019899 IPI enzyme binding
GO:0030018 IDA Z disc
GO:0030073 IMP insulin secretion
GO:0030252 IDA growth hormone secretion
GO:0030315 TAS T-tubule
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042593 IMP glucose homeostasis
GO:0043025 IDA neuronal cell body
GO:0043198 IDA dendritic shaft
GO:0046620 IMP regulation of organ growth
GO:0046872 IEA metal ion binding
GO:0051393 IEA alpha-actinin binding
GO:0060083 IMP smooth muscle contraction involved in micturition
GO:0070509 IBA calcium ion import
GO:0070588 IEA calcium ion transmembrane transport
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008398 cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit protein_coding Danio_rerio
ENSG00000151067 CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit protein_coding Homo_sapiens

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