C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: pyruvate dehydrogenase kinase, isozyme 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000282077 PDK1-001 ENSG00000152256 9606 + 2:172555969-172608669 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartLiverLungOvaryENST00000282077
Transcript ID Adrenal Brain Breast Heart Liver Lung Ovary
ENST00000282077 1.448±0.00 0.660±0.02 1.766±0.00 1.714±0.00 0.672±0.44 1.975±0.00 2.122±1.58

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004K8 CIL_0004K8_0001 CGP 2:172427354-172608669
CIL_0004KA CIL_0004KA_0001 CGP 2:172555373-173052893

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 IMP pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005739 TAS mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0006468 IEA protein phosphorylation
GO:0008283 IMP cell proliferation
GO:0008631 IMP intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 TAS regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 IMP regulation of glucose metabolic process
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0097411 IMP hypoxia-inducible factor-1alpha signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000006669 Pdk1-001 protein_coding Mus_musculus 0 1502
ENSMUST00000151358 Pdk1-003 processed_transcript Mus_musculus 0 898
ENSMUST00000134362 Pdk1-007 processed_transcript Mus_musculus 0 874
ENSMUST00000148249 Pdk1-006 processed_transcript Mus_musculus 0 623
ENSMUST00000156036 Pdk1-002 processed_transcript Mus_musculus 0 555
ENSMUST00000152696 Pdk1-004 processed_transcript Mus_musculus 0 414
ENSMUST00000129887 Pdk1-005 processed_transcript Mus_musculus 0 366
ENSMUST00000129427 Pdk1-008 processed_transcript Mus_musculus 0 265

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