C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 4, group A, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000153234 NR4A2 9606 - 2:156324432-156342348 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339562 NR4A2-001 156324432-156332716 protein_coding
  ENST00000406048 NR4A2-007 156327904-156330121 protein_coding
  ENST00000409108 NR4A2-009 156325744-156330707 protein_coding
  ENST00000409572 NR4A2-010 156325098-156342348 protein_coding
  ENST00000417764 NR4A2-011 156325100-156330788 nonsense_mediated_decay
  ENST00000417972 NR4A2-006 156325100-156331965 nonsense_mediated_decay
  ENST00000421709 NR4A2-004 156329678-156332720 protein_coding
  ENST00000424077 NR4A2-005 156329413-156332713 protein_coding
  ENST00000426264 NR4A2-003 156325082-156332714 protein_coding
  ENST00000429376 NR4A2-008 156325744-156330721 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000339562ENST00000409108ENST00000409572ENST00000417764ENST00000421709ENST00000424077ENST00000426264ENST00000429376
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000339562 3.887±0.00 0.300±0.00 N/A 0.676±0.00 4.296±0.00 1.309±0.00 2.319±0.00 N/A N/A 10.466±0.00 N/A 38.420±26.52 0.446±0.00 0.833±0.00
ENST00000409108 3.146±0.00 N/A N/A N/A N/A N/A 0.171±0.00 N/A N/A N/A N/A N/A 0.253±0.00 1.020±0.00
ENST00000409572 N/A N/A 1.737±0.00 1.089±0.00 0.616±0.00 0.347±0.00 0.108±0.00 N/A N/A 3.050±2.35 1.320±0.85 N/A 0.096±0.00 1.756±0.00
ENST00000417764 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.365±0.00 N/A
ENST00000421709 N/A N/A N/A N/A N/A N/A N/A 0.107±0.00 N/A N/A N/A N/A N/A N/A
ENST00000424077 N/A N/A N/A N/A N/A N/A N/A N/A 1.754±0.00 N/A N/A N/A N/A N/A
ENST00000426264 3.096±0.00 N/A N/A N/A N/A N/A 0.835±0.00 0.022±0.00 1.672±0.00 N/A 0.615±0.00 N/A N/A 1.834±0.00
ENST00000429376 N/A N/A N/A N/A N/A 0.458±0.00 N/A N/A N/A N/A 0.850±0.00 N/A 0.170±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000758 CIL_000758_0001 CGP 2:154698299-156342348
CIL_0007NB CIL_0007NB_0001 UCNEbase 2:155519661-157149592
CIL_0008JL CIL_0008JL_0001 VISTA 2:155834848-156435620
CIL_000759 CIL_000759_0001 CGP 2:156324432-156613735

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001666 IEA response to hypoxia
GO:0001764 IEA neuron migration
GO:0001975 IEA response to amphetamine
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0006351 IDA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 NAS signal transduction
GO:0007399 IEA nervous system development
GO:0008270 IEA zinc ion binding
GO:0008344 IEA adult locomotory behavior
GO:0009791 IEA post-embryonic development
GO:0010035 IEA response to inorganic substance
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0016265 IEA death
GO:0017085 IEA response to insecticide
GO:0021952 IEA central nervous system projection neuron axonogenesis
GO:0021953 IEA central nervous system neuron differentiation
GO:0021986 IEA habenula development
GO:0030182 IEA neuron differentiation
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031668 IDA cellular response to extracellular stimulus
GO:0034599 IEA cellular response to oxidative stress
GO:0042053 IEA regulation of dopamine metabolic process
GO:0042416 IEA dopamine biosynthetic process
GO:0042417 IEA dopamine metabolic process
GO:0042551 IEA neuron maturation
GO:0043085 IEA positive regulation of catalytic activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043576 IEA regulation of respiratory gaseous exchange
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0051866 IEA general adaptation syndrome
GO:0071542 ISS dopaminergic neuron differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017007 nr4a2a nuclear receptor subfamily 4, group A, member 2a protein_coding Danio_rerio
ENSMUSG00000026826 Nr4a2 nuclear receptor subfamily 4, group A, member 2 protein_coding Mus_musculus

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