C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 4, group A, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026826 Nr4a2 10090 - 2:57106830-57124003 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028166 Nr4a2-003 57106830-57115038 protein_coding
  ENSMUST00000112627 Nr4a2-006 57107499-57113072 protein_coding
  ENSMUST00000112629 Nr4a2-001 57106830-57124003 protein_coding
  ENSMUST00000128776 Nr4a2-004 57112990-57114373 processed_transcript
  ENSMUST00000140165 Nr4a2-005 57112003-57115038 processed_transcript
  ENSMUST00000183542 Nr4a2-002 57106830-57124003 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028166ENSMUST00000112627ENSMUST00000112629ENSMUST00000140165ENSMUST00000183542
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028166 0.574±0.11 2.010±0.54 0.297±0.01 2.547±0.57 0.197±0.11 0.570±0.19 N/A 0.125±0.03 0.083±0.00 0.565±0.23 N/A 0.338±0.13 0.151±0.07 N/A
ENSMUST00000112627 0.169±0.00 1.006±0.27 N/A N/A 0.213±0.07 0.822±0.25 0.103±0.00 0.177±0.02 0.019±0.01 N/A 0.104±0.04 0.261±0.00 0.106±0.02 0.073±0.00
ENSMUST00000112629 0.479±0.24 1.122±0.34 0.313±0.06 1.102±0.00 0.317±0.18 0.484±0.15 0.238±0.10 0.106±0.03 0.155±0.06 0.352±0.10 0.144±0.05 0.615±0.16 0.121±0.04 0.245±0.03
ENSMUST00000140165 0.420±0.00 N/A N/A N/A 0.568±0.00 N/A 0.190±0.12 0.224±0.13 0.099±0.03 N/A 0.167±0.02 N/A N/A 0.038±0.00
ENSMUST00000183542 N/A 1.000±0.35 N/A N/A 0.472±0.00 0.529±0.00 N/A N/A N/A 0.238±0.00 0.122±0.00 0.541±0.21 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000758 CIL_000758_0002 CGP 2:55435970-57124003
CIL_0007NB CIL_0007NB_0002 UCNEbase 2:56227555-57879432
CIL_0008JL CIL_0008JL_0002 VISTA 2:56616091-57216889
CIL_000759 CIL_000759_0002 CGP 2:57106830-57370719

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000977 IMP RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228 IDA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001666 IMP response to hypoxia
GO:0001764 IMP neuron migration
GO:0001975 IMP response to amphetamine
GO:0003677 IDA DNA binding
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 TAS ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006351 IEA:IDA transcription, DNA-templated
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0007399 IMP nervous system development
GO:0008270 IEA zinc ion binding
GO:0008344 IMP adult locomotory behavior
GO:0009791 IMP post-embryonic development
GO:0010035 ISO response to inorganic substance
GO:0010467 IMP gene expression
GO:0010468 IMP regulation of gene expression
GO:0016265 IMP death
GO:0017085 ISO response to insecticide
GO:0021952 IMP central nervous system projection neuron axonogenesis
GO:0021953 IMP central nervous system neuron differentiation
GO:0021986 IMP habenula development
GO:0030182 IMP neuron differentiation
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031668 ISO cellular response to extracellular stimulus
GO:0034599 IMP cellular response to oxidative stress
GO:0042053 IDA regulation of dopamine metabolic process
GO:0042416 IMP dopamine biosynthetic process
GO:0042417 IMP dopamine metabolic process
GO:0042551 IMP neuron maturation
GO:0043085 IMP positive regulation of catalytic activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 ISO sequence-specific DNA binding
GO:0043576 IMP regulation of respiratory gaseous exchange
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0051866 IMP general adaptation syndrome
GO:0071542 IDA dopaminergic neuron differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017007 nr4a2a nuclear receptor subfamily 4, group A, member 2a protein_coding Danio_rerio
ENSG00000153234 NR4A2 nuclear receptor subfamily 4, group A, member 2 protein_coding Homo_sapiens

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