C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159267 HLCS 9606 - 21:36750888-36990236 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336648 HLCS-001 36750888-36990236 protein_coding
  ENST00000399120 HLCS-002 36751192-36966473 protein_coding
  ENST00000419461 HLCS-005 36937185-36966639 protein_coding
  ENST00000427746 HLCS-004 36937214-36990224 protein_coding
  ENST00000448340 HLCS-003 36937168-36980628 protein_coding
  ENST00000482273 HLCS-006 36896570-36930417 processed_transcript
  ENST00000612277 HLCS-201 36750888-36980964 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336648ENST00000399120ENST00000612277
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336648 N/A N/A 0.548±0.02 0.302±0.00 0.323±0.00 0.597±0.00 2.620±0.00 N/A 0.385±0.00 0.389±0.00 2.583±0.96 0.362±0.00 1.638±0.17
ENST00000399120 0.482±0.00 1.566±0.00 0.374±0.00 1.181±0.15 0.194±0.00 0.386±0.04 N/A 0.690±0.12 0.424±0.02 N/A 0.687±0.00 N/A N/A
ENST00000612277 0.283±0.00 N/A 0.313±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006Z8 CIL_0006Z8_0001 CGP 21:36699133-36990236
CIL_0006ZF CIL_0006ZF_0001 CGP 21:36750888-37019659

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000785 IDA chromatin
GO:0004077 IEA biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004078 IEA biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004079 IEA biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004080 IDA biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005652 IDA nuclear lamina
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IDA cytosol
GO:0006464 IEA cellular protein modification process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0006768 TAS biotin metabolic process
GO:0008283 IMP cell proliferation
GO:0009305 IDA protein biotinylation
GO:0009374 IDA biotin binding
GO:0016363 IDA nuclear matrix
GO:0016570 IDA histone modification
GO:0018271 IMP biotin-protein ligase activity
GO:0019899 IPI enzyme binding
GO:0042803 IEA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0070781 IDA response to biotin
GO:0071110 IDA histone biotinylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039934 hlcs holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) protein_coding Danio_rerio
ENSMUSG00000040820 Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) protein_coding Mus_musculus

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