C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000399120 HLCS-002 ENSG00000159267 9606 - 21:36751192-36966473 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungOvaryENST00000399120
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Ovary
ENST00000399120 0.482±0.00 1.566±0.00 0.374±0.00 1.181±0.15 0.194±0.00 0.386±0.04 0.690±0.12 0.424±0.02 0.687±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006Z8 CIL_0006Z8_0001 CGP 21:36699133-36990236
CIL_0006ZF CIL_0006ZF_0001 CGP 21:36750888-37019659

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000785 IDA chromatin
GO:0004077 IEA biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004078 IEA biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004079 IEA biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004080 IDA biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005652 IDA nuclear lamina
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IDA cytosol
GO:0006464 IEA cellular protein modification process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0006768 TAS biotin metabolic process
GO:0008283 IMP cell proliferation
GO:0009305 IDA protein biotinylation
GO:0009374 IDA biotin binding
GO:0016363 IDA nuclear matrix
GO:0016570 IDA histone modification
GO:0018271 IMP biotin-protein ligase activity
GO:0019899 IPI enzyme binding
GO:0042803 IEA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0070781 IDA response to biotin
GO:0071110 IDA histone biotinylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000099512 Hlcs-201 protein_coding Mus_musculus 0 1522
ENSMUST00000163193 Hlcs-202 protein_coding Mus_musculus 0 1522

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