C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159352 PSMD4 9606 + 1:151254703-151267479 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368881 PSMD4-002 151254709-151267459 protein_coding
  ENST00000368884 PSMD4-001 151254703-151267479 protein_coding
  ENST00000427779 PSMD4-013 151266038-151267460 nonsense_mediated_decay
  ENST00000437736 PSMD4-014 151259063-151265609 protein_coding
  ENST00000445776 PSMD4-008 151264888-151267466 protein_coding
  ENST00000453615 PSMD4-010 151266544-151267460 protein_coding
  ENST00000461434 PSMD4-012 151254758-151262910 retained_intron
  ENST00000462970 PSMD4-004 151254763-151265588 retained_intron
  ENST00000469786 PSMD4-011 151262560-151264939 processed_transcript
  ENST00000470396 PSMD4-007 151266308-151266725 retained_intron
  ENST00000476855 PSMD4-006 151254769-151267232 retained_intron
  ENST00000491857 PSMD4-009 151265244-151266098 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368881ENST00000368884ENST00000445776ENST00000491857
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368881 12.328±0.00 13.758±0.00 N/A 13.259±0.00 23.293±0.00 17.571±0.00 16.479±0.00 22.029±0.00 8.696±0.00 14.013±0.00 24.571±0.00 15.404±5.67 N/A 17.357±0.00
ENST00000368884 25.269±0.00 29.201±0.00 7.689±0.00 40.306±6.42 23.104±3.12 27.519±13.76 16.667±4.48 21.339±2.72 26.786±2.01 16.049±2.50 83.267±43.05 51.065±23.39 84.209±12.08 73.652±16.56
ENST00000445776 N/A 25.392±0.00 N/A N/A 16.330±0.00 16.111±0.00 N/A 12.575±0.00 10.907±0.00 17.891±0.00 N/A 75.046±0.00 32.638±0.00 34.035±0.00
ENST00000491857 N/A N/A N/A N/A N/A N/A 8.824±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LW CIL_0000LW_0003 CGP 1:151197949-151267479

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008540 IEA proteasome regulatory particle, base subcomplex
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0022624 ISS proteasome accessory complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023279 psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b protein_coding Danio_rerio
ENSDARG00000036715 psmd4a proteasome (prosome, macropain) 26S subunit, non-ATPase, 4a protein_coding Danio_rerio
ENSMUSG00000005625 Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 protein_coding Mus_musculus

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