C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kalirin, RhoGEF kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160145 KALRN 9606 + 3:124080023-124726325 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000240874 KALRN-005 124094681-124519850 protein_coding
  ENST00000291478 KALRN-001 124584659-124726325 protein_coding
  ENST00000354186 KALRN-004 124227990-124721189 protein_coding
  ENST00000360013 KALRN-201 124094711-124721188 protein_coding
  ENST00000393496 KALRN-002 124504739-124675427 protein_coding
  ENST00000393501 KALRN-008 124384825-124488865 retained_intron
  ENST00000439170 KALRN-009 124334427-124395560 protein_coding
  ENST00000448253 KALRN-010 124080023-124269013 protein_coding
  ENST00000454902 KALRN-003 124584682-124650915 protein_coding
  ENST00000459915 KALRN-014 124637097-124674958 protein_coding
  ENST00000460856 KALRN-013 124094681-124519849 protein_coding
  ENST00000462213 KALRN-016 124677340-124679749 protein_coding
  ENST00000471431 KALRN-017 124562700-124632598 retained_intron
  ENST00000473056 KALRN-018 124488288-124491690 retained_intron
  ENST00000477496 KALRN-006 124080041-124164685 processed_transcript
  ENST00000483658 KALRN-007 124094753-124164686 processed_transcript
  ENST00000484224 KALRN-020 124384719-124422892 retained_intron
  ENST00000484542 KALRN-015 124674576-124678637 retained_intron
  ENST00000488825 KALRN-012 124094661-124163570 processed_transcript
  ENST00000494648 KALRN-019 124455135-124462674 retained_intron
  ENST00000498499 KALRN-021 124268591-124326085 retained_intron
  ENST00000522553 KALRN-011 124384563-124398871 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000240874ENST00000291478ENST00000354186ENST00000393496ENST00000393501ENST00000459915ENST00000460856ENST00000498499
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000240874 1.635±0.00 N/A N/A N/A N/A N/A N/A 0.832±0.00 N/A N/A N/A N/A N/A
ENST00000291478 N/A N/A 3.157±0.39 N/A 0.413±0.02 0.289±0.00 0.320±0.00 N/A N/A 0.347±0.00 N/A N/A N/A
ENST00000354186 0.763±0.00 N/A N/A N/A 0.570±0.00 0.681±0.23 0.468±0.00 0.358±0.00 0.492±0.00 0.599±0.26 0.473±0.11 N/A 0.792±0.00
ENST00000393496 4.210±0.00 N/A N/A N/A 1.371±0.00 N/A 1.772±0.00 2.769±0.00 N/A N/A 2.359±0.00 2.480±0.48 3.315±1.49
ENST00000393501 N/A 0.451±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000459915 N/A 0.781±0.00 N/A 2.683±0.00 3.903±0.00 3.598±1.64 2.390±0.26 1.202±0.00 N/A 1.748±0.48 4.057±0.32 5.253±0.00 2.705±0.00
ENST00000460856 N/A N/A 5.855±0.45 N/A N/A N/A 0.518±0.00 N/A 0.844±0.00 N/A 0.784±0.00 N/A N/A
ENST00000498499 N/A N/A N/A 19.198±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007399 ISS nervous system development
GO:0015629 TAS actin cytoskeleton
GO:0016192 TAS vesicle-mediated transport
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 ISS intracellular signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 TAS positive regulation of GTPase activity
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063538 kalrnb kalirin, RhoGEF kinase b protein_coding Danio_rerio
ENSDARG00000078117 kalrna kalirin, RhoGEF kinase a protein_coding Danio_rerio
ENSMUSG00000061751 Kalrn kalirin, RhoGEF kinase protein_coding Mus_musculus

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