C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: vav 2 guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160293 VAV2 9606 - 9:133761894-133992604 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371850 VAV2-001 133761894-133992310 protein_coding
  ENST00000371851 VAV2-002 133761894-133992604 protein_coding
  ENST00000406606 VAV2-003 133761894-133992281 protein_coding
  ENST00000472905 VAV2-005 133925851-133939301 processed_transcript
  ENST00000486113 VAV2-004 133861212-133992259 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371850ENST00000371851ENST00000406606ENST00000486113
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371850 N/A N/A N/A 0.479±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000371851 0.562±0.00 N/A N/A 0.406±0.00 0.548±0.00 N/A 1.195±0.00 3.418±0.00 0.678±0.42 1.664±1.34 N/A 1.155±0.00 N/A 0.875±0.01
ENST00000406606 2.249±0.00 7.974±0.00 2.760±0.00 1.379±0.70 1.413±0.60 2.874±1.39 0.139±0.01 6.561±2.29 4.636±3.89 3.356±2.20 0.234±0.02 8.208±6.38 7.312±0.49 5.083±1.62
ENST00000486113 N/A N/A N/A N/A 2.577±0.00 N/A 0.883±0.00 N/A 4.051±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00014Y CIL_00014Y_0001 CGP 9:133663560-133992604
CIL_00014Z CIL_00014Z_0001 CGP 9:133761894-134068535

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007165 TAS signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0010468 IMP regulation of gene expression
GO:0016477 IEA cell migration
GO:0030031 IEA cell projection assembly
GO:0030032 IEA lamellipodium assembly
GO:0030168 TAS platelet activation
GO:0030193 IMP regulation of blood coagulation
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 TAS positive regulation of GTPase activity
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044718 VAV2 vav 2 guanine nucleotide exchange factor protein_coding Danio_rerio
ENSMUSG00000009621 Vav2 vav 2 oncogene protein_coding Mus_musculus

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