C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: vav 2 guanine nucleotide exchange factor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371851 VAV2-002 ENSG00000160293 9606 - 9:133761894-133992604 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastHeartKidneyLiverLungOvaryTestisENST00000371851
Transcript ID Adipose Brain Breast Heart Kidney Liver Lung Ovary Testis
ENST00000371851 0.562±0.00 0.406±0.00 0.548±0.00 1.195±0.00 3.418±0.00 0.678±0.42 1.664±1.34 1.155±0.00 0.875±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00014Y CIL_00014Y_0001 CGP 9:133663560-133992604
CIL_00014Z CIL_00014Z_0001 CGP 9:133761894-134068535

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0007165 TAS signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0010468 IMP regulation of gene expression
GO:0030168 TAS platelet activation
GO:0030193 IMP regulation of blood coagulation
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 TAS positive regulation of GTPase activity
GO:0045087 TAS innate immune response
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000056176 Vav2-001 protein_coding Mus_musculus 0 3314
ENSMUST00000185188 Vav2-002 nonsense_mediated_decay Mus_musculus 0 2093
ENSDART00000065717 VAV2-201 protein_coding Danio_rerio 0 920
ENSDART00000143987 VAV2-001 protein_coding Danio_rerio 0 811

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