C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GDNF family receptor alpha 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168546 GFRA2 9606 - 8:21690403-21812357 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306793 GFRA2-002 21692018-21788819 nonsense_mediated_decay
  ENST00000517328 GFRA2-005 21692843-21812357 protein_coding
  ENST00000517892 GFRA2-004 21693281-21788474 protein_coding
  ENST00000518077 GFRA2-003 21692935-21788323 protein_coding
  ENST00000519195 GFRA2-007 21774976-21788784 protein_coding
  ENST00000520676 GFRA2-008 21779550-21788159 processed_transcript
  ENST00000522071 GFRA2-006 21750588-21789253 protein_coding
  ENST00000524240 GFRA2-001 21690403-21788810 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306793ENST00000517328ENST00000517892ENST00000518077ENST00000522071ENST00000524240
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306793 0.696±0.00 3.608±0.00 0.029±0.00 6.024±2.67 1.266±1.14 0.847±0.00 0.321±0.00 0.221±0.02 0.314±0.09 0.528±0.00 0.066±0.03 0.552±0.30 4.460±1.01 1.981±0.53
ENST00000517328 N/A N/A N/A N/A 0.106±0.00 N/A 0.303±0.00 N/A N/A N/A N/A N/A 2.344±0.00 0.543±0.00
ENST00000517892 N/A N/A 0.183±0.00 N/A 0.183±0.00 N/A N/A 0.119±0.00 0.679±0.00 N/A 0.169±0.00 0.271±0.20 N/A 1.171±0.00
ENST00000518077 N/A N/A N/A N/A N/A 0.494±0.00 N/A 0.130±0.00 0.168±0.00 0.360±0.21 N/A N/A N/A 1.472±0.00
ENST00000522071 N/A N/A N/A N/A N/A N/A N/A N/A 0.496±0.00 0.289±0.00 N/A N/A N/A N/A
ENST00000524240 0.119±0.00 N/A N/A N/A N/A 0.071±0.00 N/A N/A N/A N/A N/A 0.066±0.05 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000810 CIL_000810_0001 VISTA 8:21687877-22288944
CIL_0005VE CIL_0005VE_0003 CGP 8:21690403-21913860

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005886 IEA plasma membrane
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IEA nervous system development
GO:0016167 IEA glial cell-derived neurotrophic factor receptor activity
GO:0019898 TAS extrinsic component of membrane
GO:0031225 IEA anchored component of membrane
GO:0031953 IEA negative regulation of protein autophosphorylation
GO:0035860 IEA glial cell-derived neurotrophic factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042723 gfra2a glial cell line derived neurotrophic factor family receptor alpha 2a protein_coding Danio_rerio
ENSDARG00000044015 gfra2b glial cell line derived neurotrophic factor family receptor alpha 2b protein_coding Danio_rerio
ENSMUSG00000022103 Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 protein_coding Mus_musculus

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