C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: signal transducer and activator of transcription 3 (acute-phase response factor)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000264657 STAT3-001 ENSG00000168610 9606 - 17:42313324-42388568 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264657
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264657 32.917±0.00 37.606±0.00 2.716±0.00 5.322±3.17 11.402±3.47 14.799±9.77 38.503±0.00 5.035±0.00 10.179±2.76 27.947±19.09 24.772±21.55 13.702±8.90 11.475±1.04 8.155±0.96

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006IK CIL_0006IK_0001 CGP 17:42287547-42388568
CIL_00046I CIL_00046I_0001 CGP 17:42313324-42423517

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001659 ISS temperature homeostasis
GO:0001754 ISS eye photoreceptor cell differentiation
GO:0003677 ISS DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA:ISS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA:ISS cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006606 IDA protein import into nucleus
GO:0006928 TAS cellular component movement
GO:0006953 IEA acute-phase response
GO:0007165 TAS:IEA signal transduction
GO:0007259 TAS JAK-STAT cascade
GO:0007399 TAS nervous system development
GO:0008134 IPI transcription factor binding
GO:0008283 IEA cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016032 IEA viral process
GO:0016310 ISS phosphorylation
GO:0019221 NAS cytokine-mediated signaling pathway
GO:0019827 IEA stem cell maintenance
GO:0019901 ISS protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0019953 ISS sexual reproduction
GO:0030522 IDA intracellular receptor signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032355 IDA response to estradiol
GO:0032870 IDA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0035259 IEA glucocorticoid receptor binding
GO:0040014 IEA regulation of multicellular organism growth
GO:0042493 IEA response to drug
GO:0042593 ISS glucose homeostasis
GO:0042755 ISS eating behavior
GO:0043434 IEA response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045820 IEA negative regulation of glycolytic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 ISS protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048708 ISS astrocyte differentiation
GO:0060019 ISS radial glial cell differentiation
GO:0060396 IDA growth hormone receptor signaling pathway
GO:0060397 ISS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 IEA negative regulation of cell death
GO:0070102 IDA interleukin-6-mediated signaling pathway
GO:2001223 IEA negative regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000127638 Stat3-001 protein_coding Mus_musculus 0 3526
ENSMUST00000092671 Stat3-010 protein_coding Mus_musculus 0 3378
ENSMUST00000103114 Stat3-002 protein_coding Mus_musculus 0 2931
ENSMUST00000138438 Stat3-011 protein_coding Mus_musculus 0 2750
ENSDART00000080854 stat3-002 protein_coding Danio_rerio 0 1467
ENSDART00000104519 stat3-001 protein_coding Danio_rerio 0 1467
ENSMUST00000154170 Stat3-005 retained_intron Mus_musculus 0 765
ENSMUST00000156645 Stat3-003 processed_transcript Mus_musculus 0 756
ENSMUST00000152601 Stat3-013 retained_intron Mus_musculus 0 556
ENSMUST00000137093 Stat3-014 retained_intron Mus_musculus 0 527
ENSMUST00000155972 Stat3-009 retained_intron Mus_musculus 0 457
ENSMUST00000137367 Stat3-007 retained_intron Mus_musculus 0 401
ENSMUST00000130686 Stat3-004 retained_intron Mus_musculus 0 307
ENSMUST00000146971 Stat3-006 retained_intron Mus_musculus 0 196
ENSMUST00000152623 Stat3-012 retained_intron Mus_musculus 3e-34 152
ENSMUST00000189347 Stat1-008 protein_coding Mus_musculus 4e-28 132
ENSMUST00000186857 Stat1-006 protein_coding Mus_musculus 4e-28 132
ENSMUST00000191435 Stat1-007 protein_coding Mus_musculus 4e-28 132
ENSMUST00000070968 Stat1-001 protein_coding Mus_musculus 4e-28 132
ENSMUST00000186574 Stat1-004 protein_coding Mus_musculus 4e-28 132
ENSMUST00000186057 Stat1-009 protein_coding Mus_musculus 7e-16 92

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