C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Down syndrome cell adhesion molecule
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171587 DSCAM 9606 - 21:40010999-40847139 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000400454 DSCAM-001 40010999-40847139 protein_coding
  ENST00000404019 DSCAM-002 40012901-40353654 protein_coding
  ENST00000617870 DSCAM-201 40012414-40369270 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonKidneyLiverLungOvaryPlacentaTestisENST00000400454ENST00000404019ENST00000617870
Transcript ID Adipose Adrenal Brain Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000400454 N/A N/A 0.814±0.00 0.049±0.00 N/A 0.012±0.01 N/A N/A 0.123±0.05 0.056±0.00
ENST00000404019 N/A N/A 0.937±0.00 N/A 0.208±0.00 N/A 0.034±0.01 0.016±0.01 0.093±0.00 0.078±0.04
ENST00000617870 0.003±0.00 0.003±0.00 1.070±0.00 0.021±0.00 N/A 0.004±0.00 N/A 0.025±0.00 0.093±0.03 0.109±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CT CIL_0001CT_0002 CGP 21:39867317-40847139
CIL_0001CW CIL_0001CW_0002 CGP 21:40010999-41282518

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005576 IEA extracellular region
GO:0005886 ISS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0007155 IEA cell adhesion
GO:0007162 ISS negative regulation of cell adhesion
GO:0007399 TAS nervous system development
GO:0007626 IEA locomotory behavior
GO:0016020 TAS membrane
GO:0030424 ISS axon
GO:0030426 ISS growth cone
GO:0042327 IDA positive regulation of phosphorylation
GO:0048813 IEA dendrite morphogenesis
GO:0048842 IDA positive regulation of axon extension involved in axon guidance
GO:0060060 IEA post-embryonic retina morphogenesis in camera-type eye
GO:0070593 ISS dendrite self-avoidance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024865 dscama Down syndrome cell adhesion molecule a protein_coding Danio_rerio
ENSDARG00000028118 dscamb Down syndrome cell adhesion molecule b protein_coding Danio_rerio
ENSMUSG00000050272 Dscam Down syndrome cell adhesion molecule protein_coding Mus_musculus

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