C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171720 HDAC3 9606 - 5:141620876-141636870 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000305264 HDAC3-001 141620876-141636870 protein_coding
  ENST00000459727 HDAC3-012 141621485-141628562 processed_transcript
  ENST00000467533 HDAC3-005 141625701-141629972 retained_intron
  ENST00000469207 HDAC3-013 141620925-141626070 processed_transcript
  ENST00000469550 HDAC3-014 141620876-141635164 retained_intron
  ENST00000471968 HDAC3-004 141629266-141634856 retained_intron
  ENST00000475549 HDAC3-010 141626026-141626444 retained_intron
  ENST00000476739 HDAC3-008 141627899-141629224 retained_intron
  ENST00000486618 HDAC3-009 141625208-141626485 retained_intron
  ENST00000490808 HDAC3-006 141628605-141629742 retained_intron
  ENST00000491581 HDAC3-011 141624862-141627936 retained_intron
  ENST00000492407 HDAC3-007 141625750-141629258 retained_intron
  ENST00000492506 HDAC3-002 141635909-141636843 retained_intron
  ENST00000495485 HDAC3-003 141628559-141636825 retained_intron
  ENST00000519474 HDAC3-015 141627892-141636838 nonsense_mediated_decay
  ENST00000523088 HDAC3-016 141626233-141636833 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000305264ENST00000459727ENST00000469207ENST00000469550ENST00000491581ENST00000492506
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000305264 8.265±0.00 9.141±0.00 8.699±4.23 5.001±2.04 2.935±1.39 7.122±5.46 9.078±0.98 7.507±4.53 5.789±4.13 7.042±6.50 12.916±9.10 16.216±8.59 9.074±1.92
ENST00000459727 N/A N/A N/A N/A N/A N/A N/A N/A 8.976±0.00 N/A 38.043±0.00 34.826±0.00 42.920±0.00
ENST00000469207 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.240±1.74 19.322±0.00 15.372±0.00
ENST00000469550 2.006±0.00 6.170±0.00 N/A 1.500±0.00 1.181±0.28 N/A N/A N/A N/A N/A 1.457±0.00 N/A N/A
ENST00000491581 N/A N/A N/A N/A N/A N/A N/A N/A 1.213±0.00 1.477±0.00 N/A N/A N/A
ENST00000492506 N/A N/A N/A N/A N/A N/A N/A 3.047±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006QD CIL_0006QD_0001 CGP 5:141515016-141636870
CIL_0006QE CIL_0006QE_0001 CGP 5:141620876-141641077

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 TAS histone deacetylase complex
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003714 IMP transcription corepressor activity
GO:0004407 TAS:IEA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005876 IDA spindle microtubule
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IDA protein deacetylation
GO:0007219 TAS Notch signaling pathway
GO:0007346 IEA regulation of mitotic cell cycle
GO:0008134 TAS transcription factor binding
GO:0008152 IEA metabolic process
GO:0016568 TAS chromatin modification
GO:0016575 IEA histone deacetylation
GO:0016787 IEA hydrolase activity
GO:0017053 IDA transcriptional repressor complex
GO:0019899 IPI enzyme binding
GO:0030332 IPI cyclin binding
GO:0031490 IEA chromatin DNA binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 IEA circadian regulation of gene expression
GO:0033558 IDA protein deacetylase activity
GO:0040014 IEA regulation of multicellular organism growth
GO:0042826 IPI histone deacetylase binding
GO:0043066 TAS negative regulation of apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045786 TAS negative regulation of cell cycle
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046329 IMP negative regulation of JNK cascade
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051225 IMP spindle assembly
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037514 hdac3 histone deacetylase 3 protein_coding Danio_rerio
ENSMUSG00000024454 Hdac3 histone deacetylase 3 protein_coding Mus_musculus

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