C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: class II, major histocompatibility complex, transactivator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000179583 CIITA 9606 + 16:10877198-10932281 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324288 CIITA-001 10877198-10932281 protein_coding
  ENST00000381835 CIITA-002 10877210-10924437 protein_coding
  ENST00000537380 CIITA-005 10877331-10910243 processed_transcript
  ENST00000570546 CIITA-003 10877210-10924804 retained_intron
  ENST00000571186 CIITA-006 10877223-10902722 nonsense_mediated_decay
  ENST00000571190 CIITA-007 10901559-10902037 retained_intron
  ENST00000571545 CIITA-012 10928164-10932222 processed_transcript
  ENST00000572665 CIITA-009 10915646-10917010 processed_transcript
  ENST00000573309 CIITA-004 10877216-10908887 retained_intron
  ENST00000575513 CIITA-010 10922925-10923992 retained_intron
  ENST00000576601 CIITA-008 10878969-10902160 protein_coding
  ENST00000611587 CIITA-201 10877216-10908887 protein_coding
  ENST00000618207 CIITA-202 10877198-10924983 protein_coding
  ENST00000618327 CIITA-203 10877198-10924983 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000324288ENST00000537380ENST00000570546ENST00000611587ENST00000618207ENST00000618327
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000324288 6.318±0.00 N/A 0.463±0.00 N/A 0.496±0.19 0.505±0.00 N/A N/A N/A 0.234±0.00 0.948±0.29 N/A
ENST00000537380 N/A 4.448±0.00 N/A 4.924±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000570546 N/A N/A N/A N/A N/A N/A N/A N/A 1.269±0.00 N/A N/A N/A
ENST00000611587 N/A N/A N/A 1.522±0.00 N/A 0.670±0.00 N/A N/A 2.042±0.00 N/A N/A N/A
ENST00000618207 N/A N/A N/A N/A N/A N/A N/A 1.547±0.00 N/A N/A N/A N/A
ENST00000618327 N/A N/A N/A N/A N/A N/A 0.652±0.00 N/A 4.701±0.00 N/A 0.768±0.00 1.147±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000750 CIL_000750_0001 CGP 16:10760919-10932281
CIL_000751 CIL_000751_0001 CGP 16:10877198-10942460

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0003713 TAS transcription coactivator activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005525 IEA GTP binding
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006954 IEA inflammatory response
GO:0006955 TAS immune response
GO:0007568 IEA aging
GO:0008022 IPI protein C-terminus binding
GO:0009986 IEA cell surface
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016605 IDA PML body
GO:0016746 IEA transferase activity, transferring acyl groups
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032403 IDA protein complex binding
GO:0032966 IC negative regulation of collagen biosynthetic process
GO:0033613 IPI activating transcription factor binding
GO:0034341 IDA response to interferon-gamma
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045345 IDA positive regulation of MHC class I biosynthetic process
GO:0045348 IC positive regulation of MHC class II biosynthetic process
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046677 IDA response to antibiotic
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071257 IEA cellular response to electrical stimulus
GO:0071346 IEA cellular response to interferon-gamma
GO:0071360 IEA cellular response to exogenous dsRNA

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090851 ciita class II, major histocompatibility complex, transactivator protein_coding Danio_rerio
ENSMUSG00000022504 Ciita class II transactivator protein_coding Mus_musculus

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