C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, interferon-inducible double stranded RNA dependent activator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180228 PRKRA 9606 - 2:178431414-178451512 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325748 PRKRA-001 178431414-178451231 protein_coding
  ENST00000424699 PRKRA-002 178431654-178451151 nonsense_mediated_decay
  ENST00000432031 PRKRA-009 178431976-178450757 protein_coding
  ENST00000448279 PRKRA-011 178443289-178450484 nonsense_mediated_decay
  ENST00000457633 PRKRA-008 178443343-178451059 protein_coding
  ENST00000460433 PRKRA-010 178445495-178450729 processed_transcript
  ENST00000463882 PRKRA-006 178450079-178451173 retained_intron
  ENST00000466165 PRKRA-007 178447320-178451113 retained_intron
  ENST00000470200 PRKRA-005 178445426-178451512 processed_transcript
  ENST00000474793 PRKRA-012 178436274-178445883 retained_intron
  ENST00000487082 PRKRA-003 178431966-178450764 protein_coding
  ENST00000490501 PRKRA-004 178431415-178444007 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000325748ENST00000424699ENST00000432031ENST00000463882ENST00000490501
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000325748 13.807±0.00 13.018±0.00 1.782±0.00 13.384±7.53 5.447±3.46 11.133±7.85 7.915±6.54 20.987±0.00 2.407±0.11 10.309±0.00 13.010±8.68 10.624±7.42 5.977±3.66 20.529±0.00
ENST00000424699 N/A N/A N/A N/A N/A N/A 5.919±0.00 N/A N/A 4.482±0.00 11.235±0.00 N/A 1.465±0.00 11.976±0.00
ENST00000432031 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.446±0.00
ENST00000463882 N/A N/A N/A N/A N/A N/A N/A 2.762±0.00 N/A N/A 7.441±0.00 N/A N/A N/A
ENST00000490501 N/A N/A 1.265±0.00 2.754±0.00 N/A N/A N/A N/A 1.264±0.00 N/A N/A 1.128±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000Z1 CIL_0000Z1_0001 CGP 2:178194481-178451512
CIL_0000Z0 CIL_0000Z0_0001 CGP 2:178431414-178461390

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006955 TAS immune response
GO:0008047 TAS enzyme activator activity
GO:0008285 TAS negative regulation of cell proliferation
GO:0009615 TAS response to virus
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016301 IEA kinase activity
GO:0030422 IDA production of siRNA involved in RNA interference
GO:0034599 IEA cellular response to oxidative stress
GO:0042473 IEA outer ear morphogenesis
GO:0042474 IEA middle ear morphogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043085 TAS positive regulation of catalytic activity
GO:0044822 IDA poly(A) RNA binding
GO:0048705 IEA skeletal system morphogenesis
GO:2001244 IEA positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076718 prkra protein kinase, interferon-inducible double stranded RNA dependent activator protein_coding Danio_rerio
ENSMUSG00000002731 Prkra protein kinase, interferon inducible double stranded RNA dependent activator protein_coding Mus_musculus

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