C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 8 (sodium/calcium exchanger), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000183023 SLC8A1 9606 - 2:40097270-40611053 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332839 SLC8A1-201 40115253-40430280 protein_coding
  ENST00000402441 SLC8A1-006 40115113-40512435 protein_coding
  ENST00000403092 SLC8A1-010 40115031-40512361 protein_coding
  ENST00000405269 SLC8A1-012 40115250-40611053 protein_coding
  ENST00000405901 SLC8A1-003 40115045-40430304 protein_coding
  ENST00000406391 SLC8A1-202 40115253-40430280 protein_coding
  ENST00000406785 SLC8A1-005 40097270-40452069 protein_coding
  ENST00000407929 SLC8A1-011 40114731-40430271 nonsense_mediated_decay
  ENST00000408028 SLC8A1-013 40115253-40430280 protein_coding
  ENST00000417271 SLC8A1-009 40430061-40452008 protein_coding
  ENST00000448531 SLC8A1-008 40430020-40512435 protein_coding
  ENST00000455476 SLC8A1-004 40430020-40453438 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000402441ENST00000403092ENST00000405901ENST00000406391ENST00000406785ENST00000407929ENST00000408028
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000402441 N/A N/A 9.543±0.00 N/A 10.235±0.00 17.927±0.00 42.308±0.00 N/A 69.711±0.00 7.464±0.00 0.159±0.00 1.532±0.00 N/A N/A
ENST00000403092 N/A N/A N/A N/A N/A N/A 139.083±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000405901 N/A N/A N/A 31.053±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000406391 1.184±0.00 3.426±0.00 N/A N/A 0.625±0.00 N/A N/A 3.352±0.08 N/A N/A 0.774±0.64 1.079±0.32 2.308±1.17 0.751±0.52
ENST00000406785 N/A 0.512±0.00 1.137±0.00 4.021±2.92 0.565±0.31 0.790±0.36 4.881±0.00 0.259±0.00 2.661±0.00 0.552±0.15 0.035±0.01 0.168±0.07 0.445±0.00 N/A
ENST00000407929 0.436±0.00 2.582±0.00 N/A N/A 1.729±1.06 3.147±0.00 N/A 2.122±0.00 0.218±0.00 1.447±0.00 N/A 0.298±0.09 1.051±0.18 2.706±0.00
ENST00000408028 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.876±0.00 N/A 0.126±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00066Z CIL_00066Z_0001 CGP 2:39736060-40611053

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001892 IEA embryonic placenta development
GO:0002026 ISS regulation of the force of heart contraction
GO:0002027 ISS regulation of heart rate
GO:0003007 IEA heart morphogenesis
GO:0005432 IDA:IEA calcium:sodium antiporter activity
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006811 TAS ion transport
GO:0006814 IEA sodium ion transport
GO:0006816 IEA calcium ion transport
GO:0006883 IDA cellular sodium ion homeostasis
GO:0006936 TAS muscle contraction
GO:0007154 IEA cell communication
GO:0007596 TAS blood coagulation
GO:0008092 IDA cytoskeletal protein binding
GO:0009791 IEA post-embryonic development
GO:0010881 ISS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 TAS regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 ISS intercalated disc
GO:0014829 ISS vascular smooth muscle contraction
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0030018 ISS Z disc
GO:0030315 ISS T-tubule
GO:0030506 ISS ankyrin binding
GO:0034614 IDA cellular response to reactive oxygen species
GO:0035050 IEA embryonic heart tube development
GO:0035725 IEA sodium ion transmembrane transport
GO:0042383 ISS sarcolemma
GO:0044325 ISS ion channel binding
GO:0044557 ISS relaxation of smooth muscle
GO:0046872 IEA metal ion binding
GO:0048747 IEA muscle fiber development
GO:0051481 ISS negative regulation of cytosolic calcium ion concentration
GO:0055013 ISS cardiac muscle cell development
GO:0055074 ISS calcium ion homeostasis
GO:0055085 TAS:IEA transmembrane transport
GO:0055119 IC relaxation of cardiac muscle
GO:0060048 TAS cardiac muscle contraction
GO:0060401 TAS cytosolic calcium ion transport
GO:0060402 ISS calcium ion transport into cytosol
GO:0070509 IDA calcium ion import
GO:0071313 ISS cellular response to caffeine
GO:0071436 IDA sodium ion export
GO:0086012 TAS membrane depolarization during cardiac muscle cell action potential
GO:0086064 ISS cell communication by electrical coupling involved in cardiac conduction
GO:0097369 IDA sodium ion import
GO:1901660 IDA calcium ion export

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013422 slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a protein_coding Danio_rerio
ENSDARG00000043406 slc8a1b solute carrier family 8 (sodium/calcium exchanger), member 1b protein_coding Danio_rerio
ENSMUSG00000054640 Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 protein_coding Mus_musculus

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