C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuroligin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196338 NLGN3 9606 + X:71144831-71171201 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000358741 NLGN3-002 71144862-71170293 protein_coding
  ENST00000374051 NLGN3-001 71144843-71171201 protein_coding
  ENST00000395855 NLGN3-003 71144843-71167757 protein_coding
  ENST00000476589 NLGN3-004 71153456-71171199 processed_transcript
  ENST00000536169 NLGN3-201 71144831-71171199 protein_coding
  ENST00000612180 NLGN3-202 71144831-71171199 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000358741ENST00000374051ENST00000395855ENST00000476589ENST00000536169ENST00000612180
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000358741 0.100±0.00 0.328±0.00 0.165±0.00 N/A N/A N/A 0.251±0.00 0.091±0.00 N/A 0.108±0.00 0.180±0.00 N/A N/A N/A
ENST00000374051 N/A N/A N/A 7.193±0.00 N/A N/A N/A N/A 0.077±0.00 N/A N/A 2.606±1.96 0.198±0.10 N/A
ENST00000395855 0.108±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000476589 N/A 0.439±0.00 0.256±0.00 5.448±3.84 0.197±0.03 N/A 0.053±0.00 0.202±0.00 0.299±0.00 0.057±0.00 0.163±0.08 0.999±0.54 0.137±0.08 3.292±0.00
ENST00000536169 0.172±0.00 N/A N/A 4.205±2.88 0.233±0.13 N/A N/A 0.172±0.00 0.019±0.00 N/A N/A 1.639±1.28 0.268±0.08 1.229±0.00
ENST00000612180 N/A N/A N/A 5.178±0.00 N/A 1.466±0.00 N/A N/A 0.068±0.00 N/A N/A 0.765±0.00 0.226±0.13 3.176±2.55

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057X CIL_00057X_0001 CGP X:71118556-71171201
CIL_00057N CIL_00057N_0001 CGP X:71144831-71225516

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002087 ISS regulation of respiratory gaseous exchange by neurological system process
GO:0004872 ISS receptor activity
GO:0005515 IPI protein binding
GO:0005887 ISS integral component of plasma membrane
GO:0006898 ISS receptor-mediated endocytosis
GO:0007158 ISS neuron cell-cell adhesion
GO:0007416 ISS synapse assembly
GO:0007612 IMP learning
GO:0008152 IEA metabolic process
GO:0008542 IEA visual learning
GO:0009986 IDA cell surface
GO:0016787 IEA hydrolase activity
GO:0030054 IEA cell junction
GO:0030139 ISS endocytic vesicle
GO:0030534 IMP adult behavior
GO:0035176 IMP social behavior
GO:0042043 IBA neurexin family protein binding
GO:0045202 ISS synapse
GO:0048675 ISS axon extension
GO:0048709 IEA oligodendrocyte differentiation
GO:0050804 ISS regulation of synaptic transmission
GO:0050808 IMP synapse organization
GO:0050839 ISS cell adhesion molecule binding
GO:0051965 ISS positive regulation of synapse assembly
GO:0051966 IEA regulation of synaptic transmission, glutamatergic
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060024 ISS rhythmic synaptic transmission
GO:0060076 IDA excitatory synapse
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0060080 ISS regulation of inhibitory postsynaptic membrane potential
GO:0061001 IEA regulation of dendritic spine morphogenesis
GO:0071625 IMP vocalization behavior
GO:0097104 ISS postsynaptic membrane assembly
GO:0097105 ISS presynaptic membrane assembly
GO:1900271 IEA regulation of long-term synaptic potentiation
GO:2000310 IEA regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 IEA regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000331 IEA regulation of terminal button organization
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000969 ISS positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062376 nlgn3b neuroligin 3b protein_coding Danio_rerio
ENSDARG00000062581 nlgn3a neuroligin 3a protein_coding Danio_rerio
ENSMUSG00000031302 Nlgn3 neuroligin 3 protein_coding Mus_musculus

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