C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myosin VI
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196586 MYO6 9606 + 6:75749192-75919537 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000369975 MYO6-003 75817523-75916612 protein_coding
  ENST00000369977 MYO6-002 75749332-75916612 protein_coding
  ENST00000369981 MYO6-201 75749192-75919537 protein_coding
  ENST00000369985 MYO6-001 75749209-75919536 protein_coding
  ENST00000430435 MYO6-005 75890210-75908560 protein_coding
  ENST00000462633 MYO6-004 75867060-75881818 processed_transcript
  ENST00000615563 MYO6-202 75817516-75915217 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369975ENST00000369977ENST00000369981ENST00000369985ENST00000462633ENST00000615563
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369975 2.344±0.00 1.113±0.00 2.290±0.00 N/A 2.010±1.04 2.325±0.72 0.457±0.23 3.447±3.05 1.420±0.04 2.012±1.07 0.201±0.00 2.455±0.89 1.011±0.10 4.712±1.28
ENST00000369977 N/A N/A N/A 2.745±0.00 1.053±0.00 N/A N/A 3.390±2.63 N/A 1.064±0.19 0.092±0.00 0.609±0.00 0.712±0.25 1.304±0.01
ENST00000369981 N/A N/A N/A 5.181±0.00 N/A 0.569±0.00 N/A 1.744±0.00 0.967±0.00 1.130±0.00 N/A 2.389±1.55 N/A 0.823±0.00
ENST00000369985 N/A N/A N/A 0.536±0.00 N/A 0.819±0.00 0.443±0.22 N/A 1.497±0.00 1.705±0.00 N/A 0.810±0.49 N/A 2.030±0.00
ENST00000462633 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.114±0.00 N/A N/A N/A
ENST00000615563 3.327±0.00 0.992±0.00 1.792±0.00 2.253±1.05 1.931±0.00 N/A N/A 0.792±0.00 1.638±0.00 1.895±0.00 0.163±0.04 1.525±0.56 1.482±0.00 1.483±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006PS CIL_0006PS_0001 CGP 6:75601509-75919537
CIL_0006PV CIL_0006PV_0001 CGP 6:75749192-76072678

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IDA ruffle
GO:0003774 IEA motor activity
GO:0003779 TAS actin binding
GO:0005515 IPI protein binding
GO:0005516 ISS calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005765 TAS lysosomal membrane
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005902 IEA microvillus
GO:0005905 IEA coated pit
GO:0005938 ISS cell cortex
GO:0006605 IEA protein targeting
GO:0006886 ISS intracellular protein transport
GO:0006897 ISS endocytosis
GO:0007268 TAS synaptic transmission
GO:0007416 IEA synapse assembly
GO:0007605 IEA sensory perception of sound
GO:0007626 IEA locomotory behavior
GO:0008152 IEA metabolic process
GO:0012506 IEA vesicle membrane
GO:0014047 IEA glutamate secretion
GO:0016020 IDA membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016358 IEA dendrite development
GO:0016459 IEA myosin complex
GO:0016461 TAS unconventional myosin complex
GO:0016591 IDA DNA-directed RNA polymerase II, holoenzyme
GO:0030048 ISS actin filament-based movement
GO:0030139 ISS endocytic vesicle
GO:0030330 IDA DNA damage response, signal transduction by p53 class mediator
GO:0030424 IEA axon
GO:0031941 IDA filamentous actin
GO:0031965 IDA nuclear membrane
GO:0032587 IEA ruffle membrane
GO:0042472 IEA inner ear morphogenesis
GO:0042491 IEA auditory receptor cell differentiation
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043531 ISS ADP binding
GO:0045177 IEA apical part of cell
GO:0045334 IDA clathrin-coated endocytic vesicle
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048167 IEA regulation of synaptic plasticity
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048839 IEA inner ear development
GO:0051015 ISS actin filament binding
GO:0051046 IMP regulation of secretion
GO:0060001 NAS minus-end directed microfilament motor activity
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0071257 IEA cellular response to electrical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042141 myo6b myosin VIb protein_coding Danio_rerio
ENSMUSG00000033577 Myo6 myosin VI protein_coding Mus_musculus

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