C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NK2 homeobox 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000001536 Nkx2-1-002 ENSMUSG00000001496 10090 - 12:56531958-56536908 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartLiverENSMUST00000001536
Transcript ID Brain Heart Liver
ENSMUST00000001536 2.319±1.99 0.069±0.04 0.024±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LS CIL_0007LS_0003 UCNEbase 12:55566857-57467023
CIL_00092P CIL_00092P_0002 VISTA 12:56086861-56688474
CIL_0008XR CIL_0008XR_0002 VISTA 12:56140796-56741827
CIL_0008R1 CIL_0008R1_0002 VISTA 12:56154748-56756277
CIL_00091S CIL_00091S_0002 VISTA 12:56158078-56760488
CIL_0007TC CIL_0007TC_0002 VISTA 12:56181967-56783344
CIL_0007XY CIL_0007XY_0002 VISTA 12:56220183-56821029
CIL_0000SP CIL_0000SP_0002 CGP 12:56531958-56613284

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0001764 IMP neuron migration
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006644 IGI phospholipid metabolic process
GO:0007389 IGI pattern specification process
GO:0007411 IMP axon guidance
GO:0007420 IGI brain development
GO:0007492 IMP endoderm development
GO:0007626 IMP locomotory behavior
GO:0009725 IEA response to hormone
GO:0009887 IMP organ morphogenesis
GO:0010628 IEA positive regulation of gene expression
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0019899 IEA enzyme binding
GO:0021537 IMP telencephalon development
GO:0021759 IMP globus pallidus development
GO:0021766 IMP hippocampus development
GO:0021795 IMP cerebral cortex cell migration
GO:0021798 IMP forebrain dorsal/ventral pattern formation
GO:0021877 IGI forebrain neuron fate commitment
GO:0021879 IMP forebrain neuron differentiation
GO:0021892 IMP cerebral cortex GABAergic interneuron differentiation
GO:0021895 IGI cerebral cortex neuron differentiation
GO:0021983 IMP pituitary gland development
GO:0022029 IMP telencephalon cell migration
GO:0030324 IMP lung development
GO:0030336 IEA negative regulation of cell migration
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 IMP thyroid gland development
GO:0030900 IEA forebrain development
GO:0031128 IMP developmental induction
GO:0033327 IMP Leydig cell differentiation
GO:0042753 IMP positive regulation of circadian rhythm
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IGI positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048511 IEA rhythmic process
GO:0048646 IMP anatomical structure formation involved in morphogenesis
GO:0048663 IMP neuron fate commitment
GO:0048709 IGI oligodendrocyte differentiation
GO:0060430 IGI lung saccule development
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060486 IGI Clara cell differentiation
GO:0060510 IGI Type II pneumocyte differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000007829 nkx2.1a-001 protein_coding Danio_rerio 0 193
ENSDART00000153363 protein_coding Danio_rerio 0.0002 53
ENST00000258829 NKX2-8-001 protein_coding Homo_sapiens 8e-35 152
ENST00000325017 NKX2-6-001 protein_coding Homo_sapiens 9e-33 145
ENST00000329198 NKX2-5-001 protein_coding Homo_sapiens 3e-35 154
ENST00000351817 NKX2-4-001 protein_coding Homo_sapiens 0 337
ENST00000354822 NKX2-1-002 protein_coding Homo_sapiens 0 1720
ENST00000357878 HMX3-001 protein_coding Homo_sapiens 0.000000003 68
ENST00000377142 NKX2-2-001 protein_coding Homo_sapiens 1.99965e-42 178
ENST00000424406 NKX2-5-003 protein_coding Homo_sapiens 2e-35 154
ENST00000498187 NKX2-1-001 protein_coding Homo_sapiens 0 1722
ENST00000518149 NKX2-1-004 protein_coding Homo_sapiens 0 2322
ENST00000521848 NKX2-5-004 protein_coding Homo_sapiens 2e-35 154
ENST00000522719 NKX2-1-003 protein_coding Homo_sapiens 0 1657

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