C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: WW domain-containing oxidoreductase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000004756 Wwox-001 ENSMUSG00000004637 10090 + 8:114439655-115352708 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000004756
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000004756 4.897±1.21 6.061±5.19 3.146±0.05 2.591±0.50 3.734±1.38 3.387±1.43 1.025±0.25 7.261±1.56 1.391±0.33 4.627±1.38 1.196±0.09 6.961±2.38 1.301±0.64 6.228±0.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I7 CIL_0008I7_0002 VISTA 8:114199211-114800511
CIL_0007SZ CIL_0007SZ_0002 VISTA 8:114350145-114951788
CIL_00085A CIL_00085A_0002 VISTA 8:114357896-114958964
CIL_0008ID CIL_0008ID_0002 VISTA 8:114391554-114992470
CIL_0003OH CIL_0003OH_0002 CGP 8:114418086-115352708
CIL_0001PE CIL_0001PE_0002 CGP 8:114439655-115707794

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001105 NAS RNA polymerase II transcription coactivator activity
GO:0001649 IMP osteoblast differentiation
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005794 IEA Golgi apparatus
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005902 IEA microvillus
GO:0016055 IEA Wnt signaling pathway
GO:0016491 IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0030178 ISS negative regulation of Wnt signaling pathway
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048705 IMP skeletal system morphogenesis
GO:0055114 IEA oxidation-reduction process
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0072332 IGI intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001241 IDA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000355860 WWOX-001 protein_coding Homo_sapiens 0 593
ENST00000402655 WWOX-003 protein_coding Homo_sapiens 0 508
ENST00000406884 WWOX-004 protein_coding Homo_sapiens 0 593
ENST00000408984 WWOX-006 protein_coding Homo_sapiens 0 1177
ENST00000539474 WWOX-016 protein_coding Homo_sapiens 0 510
ENST00000561846 WWOX-015 processed_transcript Homo_sapiens 0 593
ENST00000562214 WWOX-008 processed_transcript Homo_sapiens 0 508
ENST00000563358 WWOX-011 processed_transcript Homo_sapiens 3e-37 159
ENST00000565562 WWOX-010 processed_transcript Homo_sapiens 0 316
ENST00000566662 WWOX-009 nonsense_mediated_decay Homo_sapiens 3.00004e-41 172
ENST00000566780 WWOX-005 protein_coding Homo_sapiens 0 1341
ENST00000569332 WWOX-002 nonsense_mediated_decay Homo_sapiens 0 1099
ENST00000569818 WWOX-007 protein_coding Homo_sapiens 1.99993e-41 172

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