C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type I, beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000019194 Scn1b 10090 - 7:31116524-31126945 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000098548 Scn1b-001 31116524-31126945 protein_coding
  ENSMUST00000187469 Scn1b-003 31117706-31125420 retained_intron
  ENSMUST00000188002 Scn1b-004 31116524-31126844 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000098548ENSMUST00000187469ENSMUST00000188002
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000098548 17.994±2.24 8.304±4.49 21.629±0.72 28.397±37.46 55.150±34.88 8.693±1.48 12.927±1.79 7.799±0.67 1.061±0.62 10.168±3.52 182.061±65.65 8.857±3.09 0.804±0.77 0.541±0.19
ENSMUST00000187469 N/A N/A N/A 189.406±0.00 73.624±0.00 N/A N/A N/A N/A N/A N/A 3.476±2.03 0.221±0.14 0.147±0.00
ENSMUST00000188002 4.383±1.34 4.328±1.08 4.639±0.36 2.129±0.05 12.509±4.74 2.667±0.92 2.382±0.17 2.677±0.32 0.539±0.24 2.970±0.49 34.765±6.72 2.800±0.92 0.466±0.45 0.336±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001VC CIL_0001VC_0002 CGP 7:31116524-31155896

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IEA voltage-gated sodium channel complex
GO:0002028 IEA regulation of sodium ion transport
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005515 IPI protein binding
GO:0007411 IMP axon guidance
GO:0010765 IEA positive regulation of sodium ion transport
GO:0010976 IGI positive regulation of neuron projection development
GO:0014704 IDA intercalated disc
GO:0017080 IEA sodium channel regulator activity
GO:0019227 IMP neuronal action potential propagation
GO:0019871 IMP sodium channel inhibitor activity
GO:0021966 IMP corticospinal neuron axon guidance
GO:0030315 IDA T-tubule
GO:0033268 IDA node of Ranvier
GO:0034706 IPI sodium channel complex
GO:0035725 IMP sodium ion transmembrane transport
GO:0040011 IMP locomotion
GO:0046684 IEA response to pyrethroid
GO:0051899 IEA membrane depolarization
GO:0060048 IEA cardiac muscle contraction
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 IEA regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337 IMP cardiac conduction
GO:0086002 IEA cardiac muscle cell action potential involved in contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086047 IEA membrane depolarization during Purkinje myocyte cell action potential
GO:0086062 IEA voltage-gated sodium channel activity involved in Purkinje myocyte action potential
GO:0086091 IEA regulation of heart rate by cardiac conduction
GO:2000649 IEA regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060222 scn1ba sodium channel, voltage-gated, type I, beta a protein_coding Danio_rerio
ENSDARG00000070170 SCN1B (2 of 3) sodium channel, voltage-gated, type I, beta subunit protein_coding Danio_rerio
ENSDARG00000071252 scn1bb sodium channel, voltage-gated, type I, beta b protein_coding Danio_rerio
ENSG00000105711 SCN1B sodium channel, voltage-gated, type I, beta subunit protein_coding Homo_sapiens

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