C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type I, beta subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105711 SCN1B 9606 + 19:35030684-35040448 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262631 SCN1B-001 35030684-35040448 protein_coding
  ENST00000415950 SCN1B-003 35030821-35034270 protein_coding
  ENST00000595652 SCN1B-002 35030733-35040073 protein_coding
  ENST00000596348 SCN1B-005 35031732-35039219 processed_transcript
  ENST00000602150 SCN1B-004 35036899-35040448 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262631ENST00000415950ENST00000595652ENST00000596348ENST00000602150
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262631 13.840±0.00 17.435±0.00 N/A 65.239±42.53 7.173±6.86 7.517±0.00 11.948±10.23 6.487±0.00 4.151±0.00 4.648±3.78 193.726±169.03 10.028±10.05 9.313±3.05 6.304±4.22
ENST00000415950 N/A N/A 0.143±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000595652 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.371±0.00 N/A
ENST00000596348 N/A N/A 0.246±0.00 N/A 4.273±0.00 1.905±0.00 1.823±0.00 1.747±0.00 3.741±0.00 N/A 55.620±0.00 0.694±0.00 N/A N/A
ENST00000602150 N/A 0.816±0.00 N/A N/A N/A 0.037±0.00 N/A 0.472±0.00 N/A 0.110±0.00 N/A 0.131±0.09 N/A 0.540±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003UF CIL_0003UF_0002 CGP 19:34994784-35040448

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IDA voltage-gated sodium channel complex
GO:0002028 IEA regulation of sodium ion transport
GO:0005248 IDA voltage-gated sodium channel activity
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0006814 IEA sodium ion transport
GO:0007155 IEA cell adhesion
GO:0007268 TAS synaptic transmission
GO:0007411 ISS axon guidance
GO:0010765 IDA positive regulation of sodium ion transport
GO:0010976 ISS positive regulation of neuron projection development
GO:0014704 ISS intercalated disc
GO:0017080 IDA sodium channel regulator activity
GO:0019227 ISS neuronal action potential propagation
GO:0019871 ISS sodium channel inhibitor activity
GO:0021966 ISS corticospinal neuron axon guidance
GO:0030315 ISS T-tubule
GO:0033268 ISS node of Ranvier
GO:0034706 IEA sodium channel complex
GO:0035725 IMP sodium ion transmembrane transport
GO:0040011 ISS locomotion
GO:0046684 IEA response to pyrethroid
GO:0051899 IDA membrane depolarization
GO:0060048 IMP cardiac muscle contraction
GO:0060307 ISS regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 IMP regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337 ISS cardiac conduction
GO:0086002 IMP cardiac muscle cell action potential involved in contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 ISS membrane depolarization during cardiac muscle cell action potential
GO:0086047 IMP membrane depolarization during Purkinje myocyte cell action potential
GO:0086062 IMP voltage-gated sodium channel activity involved in Purkinje myocyte action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:2000649 IDA regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060222 scn1ba sodium channel, voltage-gated, type I, beta a protein_coding Danio_rerio
ENSDARG00000070170 SCN1B (2 of 3) sodium channel, voltage-gated, type I, beta subunit protein_coding Danio_rerio
ENSDARG00000071252 scn1bb sodium channel, voltage-gated, type I, beta b protein_coding Danio_rerio
ENSMUSG00000019194 Scn1b sodium channel, voltage-gated, type I, beta protein_coding Mus_musculus

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