C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sterol regulatory element binding transcription factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020538 Srebf1 10090 - 11:60199089-60222581 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020846 Srebf1-005 60199089-60220604 protein_coding
  ENSMUST00000129869 Srebf1-011 60201364-60202215 processed_transcript
  ENSMUST00000134660 Srebf1-006 60199089-60207188 protein_coding
  ENSMUST00000136215 Srebf1-008 60206950-60222581 processed_transcript
  ENSMUST00000136426 Srebf1-003 60202659-60203488 processed_transcript
  ENSMUST00000141161 Srebf1-012 60200130-60201040 processed_transcript
  ENSMUST00000144942 Srebf1-007 60200463-60210465 protein_coding
  ENSMUST00000147967 Srebf1-009 60205959-60210392 processed_transcript
  ENSMUST00000149238 Srebf1-001 60203101-60204290 processed_transcript
  ENSMUST00000154620 Srebf1-010 60204189-60206112 processed_transcript
  ENSMUST00000154925 Srebf1-002 60201801-60203857 processed_transcript
  ENSMUST00000156304 Srebf1-004 60201366-60202624 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020846ENSMUST00000134660ENSMUST00000144942ENSMUST00000149238ENSMUST00000154620
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020846 40.124±2.84 73.562±18.21 32.187±12.87 12.721±1.12 95.948±29.54 37.353±10.08 4.908±0.60 15.849±3.58 28.951±22.09 35.719±6.20 6.177±2.07 30.343±11.56 14.148±3.31 2.448±1.02
ENSMUST00000134660 41.070±7.65 55.969±12.74 21.147±8.00 N/A 86.383±34.49 13.826±1.99 N/A 10.572±4.10 25.642±15.89 16.621±3.11 3.615±0.00 19.737±4.22 N/A N/A
ENSMUST00000144942 39.633±0.73 32.456±0.00 N/A N/A 75.433±0.00 N/A 4.276±0.00 6.179±0.18 18.557±7.94 N/A 6.545±1.26 9.707±0.00 N/A 1.657±0.00
ENSMUST00000149238 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 40.675±7.02 N/A
ENSMUST00000154620 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 39.440±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009A0 CIL_0009A0_0002 VISTA 11:59693037-60296757
CIL_0000NM CIL_0000NM_0002 CGP 11:59970614-60199197
CIL_00003U CIL_00003U_0003 CGP 11:60105013-60222581
CIL_00003N CIL_00003N_0003 CGP 11:60199089-60352905

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000139 TAS Golgi membrane
GO:0003062 IMP regulation of heart rate by chemical signal
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0007568 IEA aging
GO:0007623 IEP circadian rhythm
GO:0008203 IEA cholesterol metabolic process
GO:0008286 IDA insulin receptor signaling pathway
GO:0008610 IDA lipid biosynthetic process
GO:0009267 IDA cellular response to starvation
GO:0009749 IMP response to glucose
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0019217 IMP regulation of fatty acid metabolic process
GO:0019901 IPI protein kinase binding
GO:0030324 IEA lung development
GO:0031065 IDA positive regulation of histone deacetylation
GO:0031410 IEA cytoplasmic vesicle
GO:0032094 IEA response to food
GO:0032403 IEA protein complex binding
GO:0032526 IEA response to retinoic acid
GO:0032570 IEA response to progesterone
GO:0032810 ISS sterol response element binding
GO:0032869 IEA cellular response to insulin stimulus
GO:0033762 IEA response to glucagon
GO:0033993 IEA response to lipid
GO:0042493 IEA response to drug
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043434 IEA response to peptide hormone
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045542 IMP positive regulation of cholesterol biosynthetic process
GO:0045723 TAS positive regulation of fatty acid biosynthetic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046676 IMP negative regulation of insulin secretion
GO:0046983 IEA protein dimerization activity
GO:0050796 IMP regulation of insulin secretion
GO:0051591 IEA response to cAMP
GO:0070542 IEA response to fatty acid
GO:0071398 IEA cellular response to fatty acid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067607 srebf1 sterol regulatory element binding transcription factor 1 protein_coding Danio_rerio
ENSG00000072310 SREBF1 sterol regulatory element binding transcription factor 1 protein_coding Homo_sapiens

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