C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sterol regulatory element binding transcription factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000072310 SREBF1 9606 - 17:17810399-17837002 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261646 SREBF1-002 17812073-17837002 protein_coding
  ENST00000355815 SREBF1-003 17812073-17836987 protein_coding
  ENST00000395751 SREBF1-018 17812073-17820864 nonsense_mediated_decay
  ENST00000395756 SREBF1-005 17812073-17818327 nonsense_mediated_decay
  ENST00000395757 SREBF1-004 17812073-17819951 protein_coding
  ENST00000423161 SREBF1-021 17819027-17823618 protein_coding
  ENST00000447641 SREBF1-012 17814344-17816395 retained_intron
  ENST00000469356 SREBF1-010 17816525-17818742 retained_intron
  ENST00000470247 SREBF1-007 17818223-17819234 retained_intron
  ENST00000471445 SREBF1-011 17816457-17817750 retained_intron
  ENST00000476994 SREBF1-006 17820008-17823594 retained_intron
  ENST00000478616 SREBF1-015 17812910-17814355 protein_coding
  ENST00000485080 SREBF1-016 17810399-17813769 nonsense_mediated_decay
  ENST00000486311 SREBF1-014 17812712-17814376 protein_coding
  ENST00000487401 SREBF1-009 17817526-17818345 retained_intron
  ENST00000490796 SREBF1-013 17814616-17816384 retained_intron
  ENST00000577897 SREBF1-017 17819121-17820510 protein_coding
  ENST00000578469 SREBF1-026 17811356-17813442 nonsense_mediated_decay
  ENST00000580540 SREBF1-019 17817123-17817900 retained_intron
  ENST00000581707 SREBF1-020 17814403-17815373 retained_intron
  ENST00000583080 SREBF1-025 17817424-17818149 retained_intron
  ENST00000583732 SREBF1-024 17819072-17823604 processed_transcript
  ENST00000584760 SREBF1-023 17815597-17816338 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261646ENST00000355815ENST00000395751ENST00000395756ENST00000395757ENST00000470247ENST00000476994ENST00000487401ENST00000583732
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261646 5.926±0.00 11.856±0.00 1.828±0.00 10.679±0.00 5.066±3.68 2.918±0.07 1.812±1.13 6.851±0.00 11.148±0.00 14.035±0.00 3.249±0.00 16.514±11.86 8.919±2.43 7.313±0.87
ENST00000355815 N/A N/A N/A 11.175±7.67 30.994±0.00 N/A N/A 17.261±0.00 13.434±11.05 N/A 4.899±2.50 22.628±16.84 3.779±0.24 12.074±2.06
ENST00000395751 N/A N/A N/A N/A N/A 1.497±0.10 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000395756 N/A 10.074±0.00 N/A N/A N/A 3.339±0.00 N/A 5.032±0.00 19.359±0.00 N/A 3.909±0.00 9.864±0.00 5.233±0.64 16.020±0.00
ENST00000395757 N/A 7.069±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000470247 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 45.216±0.00
ENST00000476994 N/A N/A N/A N/A N/A N/A 3.522±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000487401 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.382±0.00 46.207±0.00
ENST00000583732 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.195±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009A0 CIL_0009A0_0001 VISTA 17:17235872-17840873
CIL_0000NM CIL_0000NM_0001 CGP 17:17505563-17811453
CIL_00003U CIL_00003U_0002 CGP 17:17681473-17837002
CIL_00003N CIL_00003N_0002 CGP 17:17810399-17972422

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000139 TAS Golgi membrane
GO:0003062 IEA regulation of heart rate by chemical signal
GO:0003677 ISS DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005635 TAS nuclear envelope
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006629 TAS lipid metabolic process
GO:0007568 IEA aging
GO:0007623 IEA circadian rhythm
GO:0008203 IEA cholesterol metabolic process
GO:0008286 IEA insulin receptor signaling pathway
GO:0008610 ISS lipid biosynthetic process
GO:0009267 ISS cellular response to starvation
GO:0009749 IEA response to glucose
GO:0010867 ISS positive regulation of triglyceride biosynthetic process
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019217 IEA regulation of fatty acid metabolic process
GO:0019901 IEA protein kinase binding
GO:0030324 IEA lung development
GO:0031065 IEA positive regulation of histone deacetylation
GO:0031410 IEA cytoplasmic vesicle
GO:0032094 IEA response to food
GO:0032403 IEA protein complex binding
GO:0032526 IEA response to retinoic acid
GO:0032570 IEA response to progesterone
GO:0032810 IDA sterol response element binding
GO:0032869 IEA cellular response to insulin stimulus
GO:0033762 IEA response to glucagon
GO:0033993 IEA response to lipid
GO:0042493 IEA response to drug
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043434 IEA response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045542 IEA positive regulation of cholesterol biosynthetic process
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046676 IEA negative regulation of insulin secretion
GO:0046983 IEA protein dimerization activity
GO:0050796 IEA regulation of insulin secretion
GO:0051591 IEA response to cAMP
GO:0070542 IEA response to fatty acid
GO:0071398 IEA cellular response to fatty acid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067607 srebf1 sterol regulatory element binding transcription factor 1 protein_coding Danio_rerio
ENSMUSG00000020538 Srebf1 sterol regulatory element binding transcription factor 1 protein_coding Mus_musculus

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