C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020838 Slc6a4 10090 + 11:76998603-77032340 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021195 Slc6a4-001 76998616-77032340 protein_coding
  ENSMUST00000108402 Slc6a4-003 76998603-77032339 protein_coding
  ENSMUST00000129572 Slc6a4-002 77009274-77013053 protein_coding
  ENSMUST00000137819 Slc6a4-004 77018177-77022346 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021195ENSMUST00000108402ENSMUST00000129572ENSMUST00000137819
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021195 0.400±0.36 10.125±3.87 0.411±0.01 1.894±1.37 1.222±0.73 2.325±1.12 0.640±0.29 1.071±0.29 1.063±1.09 4.232±0.65 0.072±0.04 2.372±1.01 2.543±2.66 0.593±0.28
ENSMUST00000108402 0.378±0.12 N/A N/A N/A 0.358±0.02 1.076±0.00 N/A N/A N/A N/A N/A 1.634±0.00 N/A N/A
ENSMUST00000129572 N/A 10.902±0.00 N/A N/A N/A N/A N/A N/A 0.265±0.00 N/A 0.137±0.00 2.771±0.85 N/A N/A
ENSMUST00000137819 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.031±0.01 0.601±0.35 N/A 0.025±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0005335 IEA:ISS serotonin:sodium symporter activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005829 IEA cytosol
GO:0005886 ISS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006837 IMP serotonin transport
GO:0007420 IEA brain development
GO:0007584 IEA response to nutrient
GO:0007613 IEA memory
GO:0007623 IEA circadian rhythm
GO:0008504 ISO monoamine transmembrane transporter activity
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010628 IMP positive regulation of gene expression
GO:0012505 ISS endomembrane system
GO:0015222 ISS serotonin transmembrane transporter activity
GO:0015844 ISO monoamine transport
GO:0017022 IEA myosin binding
GO:0017075 IEA syntaxin-1 binding
GO:0017137 IEA Rab GTPase binding
GO:0019811 IEA cocaine binding
GO:0021794 IEA thalamus development
GO:0021941 IEA negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 IEA negative regulation of synaptic transmission, dopaminergic
GO:0032355 IEA response to estradiol
GO:0035176 IGI social behavior
GO:0042310 IEA vasoconstriction
GO:0042493 IEA response to drug
GO:0042713 IEA sperm ejaculation
GO:0042803 IEA protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0045121 IEA membrane raft
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045787 IMP positive regulation of cell cycle
GO:0046621 IMP negative regulation of organ growth
GO:0048854 IMP brain morphogenesis
GO:0050998 IPI nitric-oxide synthase binding
GO:0051015 ISS actin filament binding
GO:0051259 ISS protein oligomerization
GO:0051260 IEA protein homooligomerization
GO:0051610 ISS serotonin uptake
GO:0055085 IEA transmembrane transport
GO:0071300 IEA cellular response to retinoic acid
GO:0071310 IDA cellular response to organic substance
GO:0071321 IEA cellular response to cGMP

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061165 slc6a4a solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A protein_coding Danio_rerio
ENSG00000108576 SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 protein_coding Homo_sapiens

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