C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 6 (neurotransmitter transporter), member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108576 SLC6A4 9606 - 17:30194319-30236002 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261707 SLC6A4-201 30194321-30235968 protein_coding
  ENST00000394821 SLC6A4-001 30198495-30235698 protein_coding
  ENST00000401766 SLC6A4-002 30194319-30236002 protein_coding
  ENST00000578609 SLC6A4-004 30198476-30203682 retained_intron
  ENST00000579221 SLC6A4-003 30197921-30211369 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261707ENST00000394821ENST00000401766ENST00000578609ENST00000579221
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261707 0.121±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.065±0.00
ENST00000394821 N/A N/A 0.146±0.00 N/A N/A 0.162±0.00 0.082±0.00 0.143±0.00 0.136±0.00 6.635±4.13 0.086±0.00 0.355±0.32 10.744±4.12 0.282±0.06
ENST00000401766 N/A 0.171±0.00 N/A 0.051±0.00 0.090±0.00 0.025±0.00 0.024±0.00 0.046±0.04 0.040±0.02 3.196±1.92 0.051±0.00 0.148±0.04 3.061±0.79 N/A
ENST00000578609 N/A N/A N/A N/A N/A N/A N/A N/A 0.096±0.00 N/A N/A N/A N/A N/A
ENST00000579221 0.114±0.00 0.163±0.00 0.379±0.00 N/A 0.169±0.00 0.448±0.00 0.062±0.00 N/A N/A 9.104±7.17 0.134±0.00 0.445±0.00 9.624±1.69 0.216±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004GG CIL_0004GG_0002 CGP 17:30194319-30292056

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0005328 IEA neurotransmitter:sodium symporter activity
GO:0005335 IEA:IMP serotonin:sodium symporter activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005887 IEA:IC integral component of plasma membrane
GO:0006836 IEA neurotransmitter transport
GO:0006837 IDA serotonin transport
GO:0007420 IEA brain development
GO:0007584 IEA response to nutrient
GO:0007613 IEA memory
GO:0007623 IEA circadian rhythm
GO:0008504 IDA monoamine transmembrane transporter activity
GO:0009636 IDA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010628 IEA positive regulation of gene expression
GO:0012505 IDA endomembrane system
GO:0015222 IMP serotonin transmembrane transporter activity
GO:0015844 IDA monoamine transport
GO:0016021 IEA integral component of membrane
GO:0017022 IEA myosin binding
GO:0017075 IEA syntaxin-1 binding
GO:0017137 IPI Rab GTPase binding
GO:0019811 IEA cocaine binding
GO:0021794 IMP thalamus development
GO:0021941 IEA negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 IEA negative regulation of synaptic transmission, dopaminergic
GO:0032355 IEA response to estradiol
GO:0035176 ISS social behavior
GO:0042310 IEA vasoconstriction
GO:0042493 IEA response to drug
GO:0042713 IEA sperm ejaculation
GO:0042803 IEA protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0045121 IDA membrane raft
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045787 IEA positive regulation of cell cycle
GO:0046621 ISS negative regulation of organ growth
GO:0048854 ISS brain morphogenesis
GO:0050998 IEA nitric-oxide synthase binding
GO:0051015 ISS actin filament binding
GO:0051259 ISS protein oligomerization
GO:0051260 IEA protein homooligomerization
GO:0051610 IDA serotonin uptake
GO:0055085 IEA transmembrane transport
GO:0071300 IEA cellular response to retinoic acid
GO:0071310 IEA cellular response to organic substance
GO:0071321 IEA cellular response to cGMP

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061165 slc6a4a solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A protein_coding Danio_rerio
ENSMUSG00000020838 Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 protein_coding Mus_musculus

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