C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000021195 Slc6a4-001 ENSMUSG00000020838 10090 + 11:76998616-77032340 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021195
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021195 0.400±0.36 10.125±3.87 0.411±0.01 1.894±1.37 1.222±0.73 2.325±1.12 0.640±0.29 1.071±0.29 1.063±1.09 4.232±0.65 0.072±0.04 2.372±1.01 2.543±2.66 0.593±0.28

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005335 IEA:ISS serotonin:sodium symporter activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005886 ISS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006837 IMP serotonin transport
GO:0008504 ISO monoamine transmembrane transporter activity
GO:0010628 IMP positive regulation of gene expression
GO:0012505 ISS endomembrane system
GO:0015222 ISS serotonin transmembrane transporter activity
GO:0015844 ISO monoamine transport
GO:0035176 IGI social behavior
GO:0045787 IMP positive regulation of cell cycle
GO:0046621 IMP negative regulation of organ growth
GO:0048854 IMP brain morphogenesis
GO:0050998 IPI nitric-oxide synthase binding
GO:0051015 ISS actin filament binding
GO:0051259 ISS protein oligomerization
GO:0051610 ISS serotonin uptake
GO:0055085 IEA transmembrane transport
GO:0071310 IDA cellular response to organic substance

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000261707 SLC6A4-201 protein_coding Homo_sapiens 0 2429
ENST00000394821 SLC6A4-001 protein_coding Homo_sapiens 0 2198
ENST00000401766 SLC6A4-002 protein_coding Homo_sapiens 0 2429
ENST00000579221 SLC6A4-003 nonsense_mediated_decay Homo_sapiens 0 584

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