C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ryanodine receptor 2, cardiac
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021313 Ryr2 10090 - 13:11553103-12106945 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021750 Ryr2-201 11553103-12106945 protein_coding
  ENSMUST00000170156 Ryr2-202 11553103-12106945 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021750ENSMUST00000170156
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021750 0.080±0.04 0.117±0.01 0.175±0.03 1.057±0.55 0.027±0.01 0.273±0.09 45.037±15.00 0.022±0.01 0.013±0.01 0.809±0.41 0.007±0.00 0.562±0.33 0.083±0.02 0.047±0.01
ENSMUST00000170156 0.017±0.00 0.117±0.01 N/A 7.304±0.00 0.027±0.01 0.213±0.03 N/A 0.022±0.01 0.008±0.01 0.293±0.00 0.007±0.00 0.498±0.27 0.059±0.03 0.046±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LI CIL_0000LI_0002 CGP 13:9875486-12106945

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0002027 IMP regulation of heart rate
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003220 IMP left ventricular cardiac muscle tissue morphogenesis
GO:0003300 IMP cardiac muscle hypertrophy
GO:0005218 IDA intracellular ligand-gated calcium channel activity
GO:0005219 IDA ryanodine-sensitive calcium-release channel activity
GO:0005262 IDA calcium channel activity
GO:0005509 IEA calcium ion binding
GO:0005513 IEA detection of calcium ion
GO:0005515 IPI protein binding
GO:0005516 IDA calmodulin binding
GO:0005790 IDA smooth endoplasmic reticulum
GO:0006816 IDA calcium ion transport
GO:0006874 IMP cellular calcium ion homeostasis
GO:0010460 IMP positive regulation of heart rate
GO:0010881 IGI regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808 IMP release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015278 IEA calcium-release channel activity
GO:0016020 IDA membrane
GO:0016021 IC integral component of membrane
GO:0016529 IDA sarcoplasmic reticulum
GO:0019722 IMP calcium-mediated signaling
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030017 IDA sarcomere
GO:0030018 IDA Z disc
GO:0030509 IDA BMP signaling pathway
GO:0031000 IDA response to caffeine
GO:0033017 IDA sarcoplasmic reticulum membrane
GO:0034236 IEA protein kinase A catalytic subunit binding
GO:0034237 IEA protein kinase A regulatory subunit binding
GO:0034704 IDA calcium channel complex
GO:0035584 IEA calcium-mediated signaling using intracellular calcium source
GO:0042802 IEA identical protein binding
GO:0043234 ISO protein complex
GO:0043621 IMP protein self-association
GO:0043924 IEA suramin binding
GO:0048763 IEA calcium-induced calcium release activity
GO:0051284 IEA positive regulation of sequestering of calcium ion
GO:0051775 IEA response to redox state
GO:0055117 IEA regulation of cardiac muscle contraction
GO:0060048 IEA cardiac muscle contraction
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060401 IMP cytosolic calcium ion transport
GO:0060402 IEA calcium ion transport into cytosol
GO:0070062 IEA extracellular vesicular exosome
GO:0070588 IMP calcium ion transmembrane transport
GO:0071313 IDA cellular response to caffeine
GO:0072599 IEA establishment of protein localization to endoplasmic reticulum
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086029 IMP Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086094 IMP positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
GO:0097050 IMP type B pancreatic cell apoptotic process
GO:0097159 IPI organic cyclic compound binding
GO:1901896 IEA positive regulation of calcium-transporting ATPase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003706 ryr2b ryanodine receptor 2b (cardiac) protein_coding Danio_rerio
ENSDARG00000056058 CABZ01065506.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000079171 ryr2a ryanodine receptor 2a (cardiac) protein_coding Danio_rerio
ENSG00000198626 RYR2 ryanodine receptor 2 (cardiac) protein_coding Homo_sapiens

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