C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ryanodine receptor 2 (cardiac)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198626 RYR2 9606 + 1:237042205-237833988 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360064 RYR2-201 237270497-237832644 protein_coding
  ENST00000366574 RYR2-001 237042205-237833988 protein_coding
  ENST00000462585 RYR2-003 237830032-237832702 processed_transcript
  ENST00000466626 RYR2-002 237800029-237802375 processed_transcript
  ENST00000608590 RYR2-004 237791846-237832758 processed_transcript
  ENST00000609119 RYR2-006 237674764-237786036 processed_transcript
  ENST00000609253 RYR2-005 237723211-237727142 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360064ENST00000366574ENST00000462585ENST00000608590ENST00000609119
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360064 N/A 0.145±0.00 0.161±0.00 N/A N/A N/A N/A N/A N/A 0.979±0.00 0.078±0.06 N/A N/A 0.244±0.00
ENST00000366574 0.113±0.00 N/A N/A 3.478±1.16 0.344±0.30 0.272±0.00 77.731±36.22 N/A 0.002±0.00 0.399±0.00 N/A 0.213±0.13 0.127±0.04 0.441±0.00
ENST00000462585 N/A N/A N/A N/A N/A N/A N/A N/A 0.036±0.00 N/A N/A N/A N/A N/A
ENST00000608590 0.234±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.095±0.00 0.439±0.00 0.576±0.00 1.305±0.00
ENST00000609119 N/A 0.272±0.00 N/A N/A 0.075±0.00 0.287±0.00 78.892±0.00 0.019±0.00 0.009±0.00 N/A N/A 0.132±0.00 0.288±0.00 0.479±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008IY CIL_0008IY_0001 VISTA 1:236697312-237300217
CIL_0008J9 CIL_0008J9_0001 VISTA 1:236711218-237313545
CIL_0008J8 CIL_0008J8_0001 VISTA 1:236729167-237332656

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 ISS response to hypoxia
GO:0002027 IMP regulation of heart rate
GO:0003143 ISS embryonic heart tube morphogenesis
GO:0003220 ISS left ventricular cardiac muscle tissue morphogenesis
GO:0003300 ISS cardiac muscle hypertrophy
GO:0005216 IEA ion channel activity
GO:0005218 ISS intracellular ligand-gated calcium channel activity
GO:0005219 IEA ryanodine-sensitive calcium-release channel activity
GO:0005262 IEA calcium channel activity
GO:0005509 IEA calcium ion binding
GO:0005513 IDA detection of calcium ion
GO:0005515 IEA protein binding
GO:0005516 ISS calmodulin binding
GO:0005790 IEA smooth endoplasmic reticulum
GO:0005886 ISS plasma membrane
GO:0006811 IEA ion transport
GO:0006816 IDA calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0010460 ISS positive regulation of heart rate
GO:0010881 ISS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014701 TAS junctional sarcoplasmic reticulum membrane
GO:0014808 ISS release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015278 IDA calcium-release channel activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016529 IDA sarcoplasmic reticulum
GO:0019722 ISS calcium-mediated signaling
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0030017 IEA sarcomere
GO:0030018 ISS Z disc
GO:0030509 IEA BMP signaling pathway
GO:0031000 IDA response to caffeine
GO:0033017 ISS sarcoplasmic reticulum membrane
GO:0034220 TAS ion transmembrane transport
GO:0034236 IDA protein kinase A catalytic subunit binding
GO:0034237 IDA protein kinase A regulatory subunit binding
GO:0034704 IDA calcium channel complex
GO:0035584 IDA calcium-mediated signaling using intracellular calcium source
GO:0042802 IPI identical protein binding
GO:0043234 IDA protein complex
GO:0043621 IEA protein self-association
GO:0043924 IMP suramin binding
GO:0044325 ISS ion channel binding
GO:0048763 IDA calcium-induced calcium release activity
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051284 IDA positive regulation of sequestering of calcium ion
GO:0051480 ISS cytosolic calcium ion homeostasis
GO:0051775 IDA response to redox state
GO:0055085 IEA transmembrane transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060048 IMP cardiac muscle contraction
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060401 IEA cytosolic calcium ion transport
GO:0060402 IDA calcium ion transport into cytosol
GO:0070062 IDA extracellular vesicular exosome
GO:0070296 TAS sarcoplasmic reticulum calcium ion transport
GO:0070588 IEA calcium ion transmembrane transport
GO:0071313 ISS cellular response to caffeine
GO:0071872 TAS cellular response to epinephrine stimulus
GO:0072599 IDA establishment of protein localization to endoplasmic reticulum
GO:0086005 ISS ventricular cardiac muscle cell action potential
GO:0086029 ISS Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086064 IC cell communication by electrical coupling involved in cardiac conduction
GO:0086094 ISS positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
GO:0097050 IMP type B pancreatic cell apoptotic process
GO:0097159 IEA organic cyclic compound binding
GO:1901896 IDA positive regulation of calcium-transporting ATPase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003706 ryr2b ryanodine receptor 2b (cardiac) protein_coding Danio_rerio
ENSDARG00000056058 CABZ01065506.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000079171 ryr2a ryanodine receptor 2a (cardiac) protein_coding Danio_rerio
ENSMUSG00000021313 Ryr2 ryanodine receptor 2, cardiac protein_coding Mus_musculus

Loading