C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ryanodine receptor 2, cardiac
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000021750 Ryr2-201 ENSMUSG00000021313 10090 - 13:11553103-12106945 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021750
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021750 0.080±0.04 0.117±0.01 0.175±0.03 1.057±0.55 0.027±0.01 0.273±0.09 45.037±15.00 0.022±0.01 0.013±0.01 0.809±0.41 0.007±0.00 0.562±0.33 0.083±0.02 0.047±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LI CIL_0000LI_0002 CGP 13:9875486-12106945

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0002027 IMP regulation of heart rate
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003220 IMP left ventricular cardiac muscle tissue morphogenesis
GO:0003300 IMP cardiac muscle hypertrophy
GO:0005218 IDA intracellular ligand-gated calcium channel activity
GO:0005219 IDA ryanodine-sensitive calcium-release channel activity
GO:0005262 IDA calcium channel activity
GO:0005509 IEA calcium ion binding
GO:0005513 IEA detection of calcium ion
GO:0005515 IPI protein binding
GO:0005516 IDA calmodulin binding
GO:0005790 IDA smooth endoplasmic reticulum
GO:0006816 IDA calcium ion transport
GO:0006874 IMP cellular calcium ion homeostasis
GO:0010460 IMP positive regulation of heart rate
GO:0010881 IGI regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808 IMP release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015278 IEA calcium-release channel activity
GO:0016020 IDA membrane
GO:0016021 IC integral component of membrane
GO:0016529 IDA sarcoplasmic reticulum
GO:0019722 IMP calcium-mediated signaling
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030017 IDA sarcomere
GO:0030018 IDA Z disc
GO:0030509 IDA BMP signaling pathway
GO:0031000 IDA response to caffeine
GO:0033017 IDA sarcoplasmic reticulum membrane
GO:0034236 IEA protein kinase A catalytic subunit binding
GO:0034237 IEA protein kinase A regulatory subunit binding
GO:0034704 IDA calcium channel complex
GO:0035584 IEA calcium-mediated signaling using intracellular calcium source
GO:0042802 IEA identical protein binding
GO:0043234 ISO protein complex
GO:0043621 IMP protein self-association
GO:0043924 IEA suramin binding
GO:0048763 IEA calcium-induced calcium release activity
GO:0051284 IEA positive regulation of sequestering of calcium ion
GO:0051775 IEA response to redox state
GO:0055117 IEA regulation of cardiac muscle contraction
GO:0060048 IEA cardiac muscle contraction
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060401 IMP cytosolic calcium ion transport
GO:0060402 IEA calcium ion transport into cytosol
GO:0070062 IEA extracellular vesicular exosome
GO:0070588 IMP calcium ion transmembrane transport
GO:0071313 IDA cellular response to caffeine
GO:0072599 IEA establishment of protein localization to endoplasmic reticulum
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086029 IMP Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086094 IMP positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
GO:0097050 IMP type B pancreatic cell apoptotic process
GO:0097159 IPI organic cyclic compound binding
GO:1901896 IEA positive regulation of calcium-transporting ATPase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000147464 ryr3-001 protein_coding Danio_rerio 0 815
ENSDART00000149737 ryr2b-001 protein_coding Danio_rerio 0 793
ENSDART00000036015 ryr1b-201 protein_coding Danio_rerio 0 732
ENSDART00000026272 ryr2b-201 protein_coding Danio_rerio 0 691
ENSDART00000078464 CABZ01065506.1-201 protein_coding Danio_rerio 0.0003 55
ENST00000360064 RYR2-201 protein_coding Homo_sapiens 0 14800
ENST00000366574 RYR2-001 protein_coding Homo_sapiens 0 16850
ENST00000389232 RYR3-001 protein_coding Homo_sapiens 0 883
ENST00000415757 RYR3-002 protein_coding Homo_sapiens 0 883
ENST00000462585 RYR2-003 processed_transcript Homo_sapiens 0 351
ENST00000608590 RYR2-004 processed_transcript Homo_sapiens 0 1249
ENST00000609119 RYR2-006 processed_transcript Homo_sapiens 0 2228
ENST00000622037 RYR3-201 protein_coding Homo_sapiens 0 876

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