C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor AP-2, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021359 Tfap2a 10090 - 13:40715675-40733823 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021787 Tfap2a-201 40715675-40730418 protein_coding
  ENSMUST00000110193 Tfap2a-202 40715675-40733823 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021787ENSMUST00000110193
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021787 N/A N/A 0.068±0.00 2.451±1.65 1.198±0.73 0.022±0.01 N/A 0.619±0.25 N/A 0.391±0.27 N/A N/A 0.487±0.34 0.128±0.03
ENSMUST00000110193 0.050±0.02 0.050±0.04 0.108±0.00 1.498±1.71 0.704±0.30 0.041±0.01 0.034±0.02 0.700±0.32 0.027±0.02 0.154±0.00 0.044±0.01 0.091±0.05 1.946±1.77 0.237±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007NC CIL_0007NC_0002 UCNEbase 13:38708565-40726483
CIL_00097A CIL_00097A_0002 VISTA 13:40412299-41013499
CIL_00086X CIL_00086X_0002 VISTA 13:40425554-41028254
CIL_000382 CIL_000382_0002 CGP 13:40715675-40960891

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001106 IDA RNA polymerase II transcription corepressor activity
GO:0001228 IDA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001822 ISS kidney development
GO:0001843 IMP neural tube closure
GO:0002089 IMP lens morphogenesis in camera-type eye
GO:0003151 IMP outflow tract morphogenesis
GO:0003334 IGI keratinocyte development
GO:0003404 IMP optic vesicle morphogenesis
GO:0003409 IMP optic cup structural organization
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 ISS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 TAS transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005813 IEA centrosome
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007399 IEP nervous system development
GO:0007423 IEP sensory organ development
GO:0007605 ISS sensory perception of sound
GO:0008285 IMP negative regulation of cell proliferation
GO:0009880 IMP embryonic pattern specification
GO:0010172 IMP embryonic body morphogenesis
GO:0010628 IDA positive regulation of gene expression
GO:0010842 IEA retina layer formation
GO:0010944 ISS negative regulation of transcription by competitive promoter binding
GO:0014032 IMP neural crest cell development
GO:0021506 IMP anterior neuropore closure
GO:0021559 IMP trigeminal nerve development
GO:0021623 IMP oculomotor nerve formation
GO:0021884 IMP forebrain neuron development
GO:0030335 IMP positive regulation of cell migration
GO:0030501 ISS positive regulation of bone mineralization
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035136 IMP forelimb morphogenesis
GO:0042059 IMP negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 ISS inner ear morphogenesis
GO:0043066 ISS negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043588 IGI skin development
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045595 IEA regulation of cell differentiation
GO:0045664 IMP regulation of neuron differentiation
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0048485 IGI sympathetic nervous system development
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048705 IMP skeletal system morphogenesis
GO:0048730 IMP epidermis morphogenesis
GO:0060021 ISS palate development
GO:0060235 IMP lens induction in camera-type eye
GO:0060325 IMP face morphogenesis
GO:0060349 IMP bone morphogenesis
GO:0061029 IMP eyelid development in camera-type eye
GO:0061303 IMP cornea development in camera-type eye
GO:0070172 ISS positive regulation of tooth mineralization
GO:0071281 ISS cellular response to iron ion
GO:0071711 IMP basement membrane organization
GO:0072210 IEP metanephric nephron development
GO:2000378 ISS negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059279 tfap2a transcription factor AP-2 alpha protein_coding Danio_rerio
ENSG00000137203 TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) protein_coding Homo_sapiens

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