C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137203 TFAP2A 9606 - 6:10393186-10419659 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000319516 TFAP2A-003 10397872-10419638 protein_coding
  ENST00000379604 TFAP2A-201 10396683-10415237 protein_coding
  ENST00000379608 TFAP2A-005 10397915-10412374 protein_coding
  ENST00000379613 TFAP2A-001 10396677-10415248 protein_coding
  ENST00000461628 TFAP2A-017 10393186-10404594 protein_coding
  ENST00000462727 TFAP2A-014 10406794-10410942 processed_transcript
  ENST00000464323 TFAP2A-006 10409086-10419554 retained_intron
  ENST00000465858 TFAP2A-016 10409997-10412879 protein_coding
  ENST00000466073 TFAP2A-010 10398602-10414985 protein_coding
  ENST00000473652 TFAP2A-013 10404668-10419659 processed_transcript
  ENST00000474952 TFAP2A-012 10406136-10412046 retained_intron
  ENST00000475264 TFAP2A-018 10400714-10410094 protein_coding
  ENST00000478375 TFAP2A-002 10402026-10414985 retained_intron
  ENST00000482890 TFAP2A-007 10398013-10416190 protein_coding
  ENST00000486038 TFAP2A-019 10418189-10419623 processed_transcript
  ENST00000488193 TFAP2A-008 10397915-10415206 nonsense_mediated_decay
  ENST00000489805 TFAP2A-011 10397410-10412175 nonsense_mediated_decay
  ENST00000490875 TFAP2A-004 10404621-10417207 processed_transcript
  ENST00000497266 TFAP2A-015 10398688-10411018 processed_transcript
  ENST00000498450 TFAP2A-009 10402538-10415000 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000319516ENST00000379604ENST00000379608ENST00000379613ENST00000464323ENST00000466073ENST00000474952ENST00000475264ENST00000478375ENST00000482890ENST00000488193ENST00000489805ENST00000497266ENST00000498450
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000319516 0.053±0.00 N/A 0.798±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000379604 0.031±0.00 N/A N/A 0.076±0.00 0.319±0.26 N/A N/A 2.454±0.00 0.003±0.00 N/A 0.347±0.00 13.644±7.07 N/A
ENST00000379608 0.058±0.00 N/A 0.406±0.00 N/A N/A N/A N/A N/A N/A 0.147±0.00 0.404±0.00 9.734±3.08 0.631±0.00
ENST00000379613 N/A N/A N/A N/A N/A N/A N/A N/A 0.002±0.00 N/A N/A N/A N/A
ENST00000464323 N/A N/A 0.478±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000466073 0.318±0.00 N/A N/A N/A N/A 0.509±0.00 N/A N/A N/A N/A 9.731±0.00 23.330±0.00 N/A
ENST00000474952 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.083±0.00 3.565±0.00 N/A 0.646±0.00
ENST00000475264 N/A N/A N/A N/A 1.049±0.00 0.178±0.00 N/A N/A N/A N/A N/A 23.617±0.00 2.638±0.00
ENST00000478375 N/A 0.061±0.00 N/A N/A N/A N/A 0.016±0.00 N/A N/A N/A N/A N/A N/A
ENST00000482890 N/A N/A N/A N/A 0.279±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000488193 N/A N/A 0.522±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000489805 N/A 0.043±0.00 N/A N/A N/A 0.299±0.00 0.013±0.00 0.549±0.53 N/A N/A 2.442±0.00 10.300±0.00 1.183±0.00
ENST00000497266 N/A N/A N/A N/A N/A N/A N/A N/A 0.058±0.00 N/A N/A N/A N/A
ENST00000498450 N/A N/A N/A N/A N/A N/A 0.025±0.00 N/A N/A N/A N/A N/A 5.099±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007NC CIL_0007NC_0001 UCNEbase 6:8153140-10408054
CIL_00097A CIL_00097A_0001 VISTA 6:10093642-10694839
CIL_00086X CIL_00086X_0001 VISTA 6:10107199-10709812
CIL_000382 CIL_000382_0001 CGP 6:10393186-10629368

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001105 IEA RNA polymerase II transcription coactivator activity
GO:0001106 IEA RNA polymerase II transcription corepressor activity
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001822 IMP kidney development
GO:0001843 IEA neural tube closure
GO:0002089 IEA lens morphogenesis in camera-type eye
GO:0003151 IEA outflow tract morphogenesis
GO:0003334 IEA keratinocyte development
GO:0003404 ISS optic vesicle morphogenesis
GO:0003409 ISS optic cup structural organization
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005813 IDA centrosome
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007399 IEA nervous system development
GO:0007423 IEA sensory organ development
GO:0007605 IMP sensory perception of sound
GO:0008285 IDA negative regulation of cell proliferation
GO:0009880 IEA embryonic pattern specification
GO:0010172 IEA embryonic body morphogenesis
GO:0010628 ISS positive regulation of gene expression
GO:0010842 IEP retina layer formation
GO:0010944 IMP negative regulation of transcription by competitive promoter binding
GO:0014032 IEA neural crest cell development
GO:0021506 IEA anterior neuropore closure
GO:0021559 ISS trigeminal nerve development
GO:0021623 ISS oculomotor nerve formation
GO:0021884 IEA forebrain neuron development
GO:0030335 IEA positive regulation of cell migration
GO:0030501 IDA positive regulation of bone mineralization
GO:0035115 ISS embryonic forelimb morphogenesis
GO:0035136 IEA forelimb morphogenesis
GO:0042059 IEA negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 IMP inner ear morphogenesis
GO:0042803 TAS protein homodimerization activity
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043588 IEA skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045595 IDA regulation of cell differentiation
GO:0045664 IEA regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IDA protein dimerization activity
GO:0048485 IEA sympathetic nervous system development
GO:0048596 IEA embryonic camera-type eye morphogenesis
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0048730 IEA epidermis morphogenesis
GO:0060021 IMP palate development
GO:0060235 IEA lens induction in camera-type eye
GO:0060325 IEA face morphogenesis
GO:0060349 ISS bone morphogenesis
GO:0061029 ISS eyelid development in camera-type eye
GO:0061303 IEA cornea development in camera-type eye
GO:0070172 IDA positive regulation of tooth mineralization
GO:0071281 IDA cellular response to iron ion
GO:0071711 IEA basement membrane organization
GO:0072210 IEA metanephric nephron development
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059279 tfap2a transcription factor AP-2 alpha protein_coding Danio_rerio
ENSMUSG00000021359 Tfap2a transcription factor AP-2, alpha protein_coding Mus_musculus

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