C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: receptor tyrosine kinase-like orphan receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021464 Ror2 10090 - 13:53109312-53286124 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021918 Ror2-001 53109317-53286124 protein_coding
  ENSMUST00000130235 Ror2-002 53109312-53285549 protein_coding
  ENSMUST00000149299 Ror2-003 53131960-53275658 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021918ENSMUST00000130235
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021918 6.795±6.25 2.464±0.58 3.152±0.21 1.168±0.01 1.904±0.73 6.245±1.29 0.478±0.10 1.642±0.45 0.096±0.05 1.296±0.53 0.135±0.00 4.413±1.88 1.115±0.34 0.281±0.08
ENSMUST00000130235 0.515±0.02 1.829±0.45 N/A 0.133±0.00 0.985±0.51 2.272±1.18 0.293±0.00 0.605±0.00 0.056±0.04 0.720±0.00 0.085±0.03 1.607±0.54 0.452±0.08 0.820±0.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00068R CIL_00068R_0002 CGP 13:52967209-53286124
CIL_0002JG CIL_0002JG_0002 CGP 13:53109312-53377365

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IMP skeletal system development
GO:0001502 IMP cartilage condensation
GO:0001756 IMP somitogenesis
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0005109 IPI frizzled binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005886 TAS plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223 IPI Wnt signaling pathway, calcium modulating pathway
GO:0007254 IDA JNK cascade
GO:0008285 IEA negative regulation of cell proliferation
GO:0017147 IPI Wnt-protein binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030154 IMP cell differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0030538 IMP embryonic genitalia morphogenesis
GO:0042472 IMP inner ear morphogenesis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0060071 IMP Wnt signaling pathway, planar cell polarity pathway
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076227 ror2 receptor tyrosine kinase-like orphan receptor 2 protein_coding Danio_rerio
ENSG00000169071 ROR2 receptor tyrosine kinase-like orphan receptor 2 protein_coding Homo_sapiens

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