C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: zinc finger E-box binding homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024238 Zeb1 10090 + 18:5591860-5775467 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025081 Zeb1-001 5591860-5775467 protein_coding
  ENSMUST00000159390 Zeb1-008 5591891-5766533 protein_coding
  ENSMUST00000159477 Zeb1-005 5603744-5642873 processed_transcript
  ENSMUST00000160522 Zeb1-002 5591872-5706884 retained_intron
  ENSMUST00000160910 Zeb1-006 5593602-5759057 protein_coding
  ENSMUST00000161295 Zeb1-007 5591912-5766570 nonsense_mediated_decay
  ENSMUST00000162892 Zeb1-009 5594203-5767742 retained_intron
  ENSMUST00000175739 Zeb1-004 5593308-5641459 processed_transcript
  ENSMUST00000175925 Zeb1-010 5591891-5766916 nonsense_mediated_decay
  ENSMUST00000177030 Zeb1-003 5731081-5772804 processed_transcript
  ENSMUST00000177070 Zeb1-011 5593861-5759184 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025081ENSMUST00000177030
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025081 7.993±2.70 2.705±0.00 7.067±1.98 10.000±6.23 6.535±2.01 1.556±0.37 6.263±0.24 2.118±0.85 2.070±1.14 8.594±0.98 4.888±1.10 6.884±2.72 2.031±0.79 1.886±0.52
ENSMUST00000177030 N/A 2.502±0.40 N/A 15.363±0.00 2.104±0.00 N/A N/A N/A N/A N/A N/A 4.755±3.57 1.583±0.59 2.131±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000R6 CIL_0000R6_0002 CGP 18:5210031-5775467
CIL_0000R1 CIL_0000R1_0002 CGP 18:5591860-6136098

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0003676 IEA nucleic acid binding
GO:0003682 IDA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0007389 IMP pattern specification process
GO:0007417 IGI central nervous system development
GO:0008134 IPI transcription factor binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0010464 IMP regulation of mesenchymal cell proliferation
GO:0014823 IEA response to activity
GO:0017015 IGI regulation of transforming growth factor beta receptor signaling pathway
GO:0030857 IMP negative regulation of epithelial cell differentiation
GO:0030900 IEA forebrain development
GO:0031667 IEA response to nutrient levels
GO:0033081 IMP regulation of T cell differentiation in thymus
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048513 IMP organ development
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0048598 IGI embryonic morphogenesis
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0048752 IMP semicircular canal morphogenesis
GO:0051150 IMP regulation of smooth muscle cell differentiation
GO:0051216 IMP cartilage development
GO:0070888 IDA E-box binding
GO:0071230 IDA cellular response to amino acid stimulus
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0090103 IMP cochlea morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013207 zeb1b zinc finger E-box binding homeobox 1b protein_coding Danio_rerio
ENSDARG00000016788 zeb1a zinc finger E-box binding homeobox 1a protein_coding Danio_rerio
ENSG00000148516 ZEB1 zinc finger E-box binding homeobox 1 protein_coding Homo_sapiens

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