C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: zinc finger E-box binding homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000148516 ZEB1 9606 + 10:31318495-31529814 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000320985 ZEB1-018 31319125-31529202 protein_coding
  ENST00000361642 ZEB1-201 31319172-31529813 protein_coding
  ENST00000424869 ZEB1-004 31319216-31520200 protein_coding
  ENST00000437844 ZEB1-001 31319216-31529814 nonsense_mediated_decay
  ENST00000446923 ZEB1-202 31321135-31529813 protein_coding
  ENST00000488625 ZEB1-005 31318495-31529202 retained_intron
  ENST00000493835 ZEB1-006 31355144-31461236 processed_transcript
  ENST00000542815 ZEB1-016 31319222-31527294 protein_coding
  ENST00000542879 ZEB1-017 31318818-31527276 retained_intron
  ENST00000557827 ZEB1-013 31321474-31514651 retained_intron
  ENST00000558440 ZEB1-003 31319213-31520421 protein_coding
  ENST00000558655 ZEB1-009 31320547-31524007 retained_intron
  ENST00000558832 ZEB1-021 31322010-31358590 processed_transcript
  ENST00000558863 ZEB1-019 31320113-31520811 retained_intron
  ENST00000559476 ZEB1-012 31321152-31520214 protein_coding
  ENST00000559496 ZEB1-011 31321135-31514657 retained_intron
  ENST00000559858 ZEB1-015 31319212-31524007 processed_transcript
  ENST00000560196 ZEB1-007 31318783-31502447 retained_intron
  ENST00000560721 ZEB1-002 31319212-31527294 protein_coding
  ENST00000560909 ZEB1-023 31381723-31461180 retained_intron
  ENST00000561061 ZEB1-010 31320606-31514707 processed_transcript
  ENST00000561212 ZEB1-020 31320126-31520811 protein_coding
  ENST00000561304 ZEB1-008 31318837-31514681 retained_intron
  ENST00000606161 ZEB1-022 31321690-31502406 processed_transcript
  ENST00000606671 ZEB1-024 31321621-31502423 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000320985ENST00000361642ENST00000424869ENST00000437844ENST00000446923ENST00000488625ENST00000542815ENST00000542879ENST00000557827ENST00000558440ENST00000558655ENST00000559858ENST00000560721
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000320985 11.603±0.00 4.575±0.00 N/A 7.286±0.00 5.094±2.35 10.748±9.40 4.013±2.34 0.980±0.00 4.864±3.79 12.393±0.00 15.006±0.00 2.213±1.65 2.456±0.92 5.510±2.61
ENST00000361642 2.843±0.00 N/A N/A N/A N/A N/A N/A 0.799±0.00 N/A N/A N/A 1.314±0.11 1.191±0.48 N/A
ENST00000424869 N/A N/A N/A N/A 9.045±0.00 10.238±0.00 7.016±0.00 N/A 21.203±0.00 10.281±0.00 N/A N/A N/A N/A
ENST00000437844 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.902±0.00 N/A N/A
ENST00000446923 N/A N/A N/A 2.153±0.28 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000488625 N/A N/A N/A N/A 1.385±0.00 N/A 1.365±0.00 0.654±0.00 N/A 2.733±0.00 0.365±0.00 0.372±0.00 N/A 1.734±0.00
ENST00000542815 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.387±0.00 N/A N/A N/A N/A
ENST00000542879 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.957±0.00 N/A N/A 2.577±0.00
ENST00000557827 N/A N/A N/A N/A N/A N/A N/A 2.760±0.00 N/A N/A N/A N/A N/A N/A
ENST00000558440 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.048±0.00 N/A N/A N/A
ENST00000558655 N/A N/A 1.838±0.00 N/A N/A N/A 3.562±0.00 N/A 8.487±0.00 N/A N/A 2.346±0.00 N/A N/A
ENST00000559858 N/A N/A N/A 4.275±0.00 7.280±0.00 3.137±0.00 N/A N/A 9.139±0.00 4.586±0.00 2.161±0.00 N/A N/A N/A
ENST00000560721 N/A N/A 0.580±0.00 2.571±0.00 N/A N/A N/A N/A N/A N/A N/A 1.122±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000R6 CIL_0000R6_0001 CGP 10:30820207-31529814
CIL_0000R1 CIL_0000R1_0001 CGP 10:31318495-31928876

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 TAS transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006955 TAS immune response
GO:0007389 IEA pattern specification process
GO:0007417 IEA central nervous system development
GO:0008134 IEA transcription factor binding
GO:0008270 TAS zinc ion binding
GO:0008283 TAS cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010464 IEA regulation of mesenchymal cell proliferation
GO:0014823 IEA response to activity
GO:0017015 IEA regulation of transforming growth factor beta receptor signaling pathway
GO:0030857 IEA negative regulation of epithelial cell differentiation
GO:0030900 IEA forebrain development
GO:0031667 IEA response to nutrient levels
GO:0033081 IEA regulation of T cell differentiation in thymus
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048513 IEA organ development
GO:0048596 IEA embryonic camera-type eye morphogenesis
GO:0048598 IEA embryonic morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0048752 IEA semicircular canal morphogenesis
GO:0051150 IEA regulation of smooth muscle cell differentiation
GO:0051216 IEA cartilage development
GO:0070888 ISS E-box binding
GO:0071230 IEA cellular response to amino acid stimulus
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0090103 IEA cochlea morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013207 zeb1b zinc finger E-box binding homeobox 1b protein_coding Danio_rerio
ENSDARG00000016788 zeb1a zinc finger E-box binding homeobox 1a protein_coding Danio_rerio
ENSMUSG00000024238 Zeb1 zinc finger E-box binding homeobox 1 protein_coding Mus_musculus

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