C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 7 like 2, T cell specific, HMG box
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024985 Tcf7l2 10090 + 19:55741810-55933654 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041717 Tcf7l2-012 55741820-55933252 protein_coding
  ENSMUST00000061496 Tcf7l2-201 55741810-55933654 protein_coding
  ENSMUST00000111646 Tcf7l2-007 55895510-55933229 protein_coding
  ENSMUST00000111649 Tcf7l2-002 55742243-55912722 protein_coding
  ENSMUST00000111651 Tcf7l2-004 55742243-55912723 protein_coding
  ENSMUST00000111652 Tcf7l2-003 55742242-55912723 protein_coding
  ENSMUST00000111653 Tcf7l2-010 55742269-55925236 protein_coding
  ENSMUST00000111654 Tcf7l2-011 55741884-55925239 protein_coding
  ENSMUST00000111656 Tcf7l2-006 55742332-55933654 protein_coding
  ENSMUST00000111657 Tcf7l2-202 55741810-55933654 protein_coding
  ENSMUST00000111658 Tcf7l2-001 55741884-55932715 protein_coding
  ENSMUST00000111659 Tcf7l2-009 55742058-55932209 protein_coding
  ENSMUST00000111662 Tcf7l2-203 55741820-55933229 protein_coding
  ENSMUST00000126434 Tcf7l2-013 55742269-55910549 retained_intron
  ENSMUST00000127233 Tcf7l2-008 55742364-55933231 protein_coding
  ENSMUST00000127653 Tcf7l2-017 55895662-55912637 processed_transcript
  ENSMUST00000133008 Tcf7l2-014 55742845-55910681 retained_intron
  ENSMUST00000142291 Tcf7l2-018 55894534-55918966 protein_coding
  ENSMUST00000143334 Tcf7l2-016 55898309-55919041 processed_transcript
  ENSMUST00000145249 Tcf7l2-019 55893352-55919618 processed_transcript
  ENSMUST00000148666 Tcf7l2-015 55898553-55919604 protein_coding
  ENSMUST00000153888 Tcf7l2-005 55742468-55932209 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041717ENSMUST00000061496ENSMUST00000111646ENSMUST00000111656ENSMUST00000111657ENSMUST00000111658ENSMUST00000111659ENSMUST00000111662ENSMUST00000127233ENSMUST00000145249ENSMUST00000153888
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041717 2.102±0.42 N/A 2.042±0.70 N/A 2.452±0.68 8.551±1.90 1.355±0.83 2.070±0.68 1.542±0.48 3.119±0.56 0.296±0.00 3.294±0.91 1.071±0.55 0.985±0.54
ENSMUST00000061496 2.003±0.17 0.812±0.00 3.614±0.75 14.527±5.41 2.066±0.68 6.568±1.70 0.754±0.00 1.198±0.15 1.261±0.31 2.033±0.48 0.276±0.13 1.564±0.28 1.922±0.86 0.990±0.31
ENSMUST00000111646 N/A N/A N/A 31.149±22.83 3.016±0.00 N/A N/A N/A 2.123±0.00 N/A N/A 1.384±0.00 0.472±0.00 N/A
ENSMUST00000111656 N/A N/A N/A 19.914±14.58 N/A N/A N/A N/A 1.762±0.18 N/A 0.364±0.14 N/A N/A N/A
ENSMUST00000111657 N/A N/A 1.528±0.00 N/A N/A N/A 0.821±0.17 N/A 3.680±0.00 N/A 0.242±0.08 N/A 1.073±0.21 N/A
ENSMUST00000111658 N/A 1.048±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000111659 1.503±0.00 2.095±0.30 N/A N/A 3.224±0.66 N/A N/A N/A N/A N/A N/A 3.048±0.91 N/A N/A
ENSMUST00000111662 N/A N/A N/A N/A 1.538±0.00 N/A N/A N/A N/A N/A N/A 1.752±0.78 N/A N/A
ENSMUST00000127233 N/A 1.697±0.17 N/A 0.746±0.00 N/A N/A N/A 1.863±0.32 N/A N/A 0.369±0.00 N/A N/A N/A
ENSMUST00000145249 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.667±0.00
ENSMUST00000153888 4.411±0.76 5.033±0.55 2.063±0.00 N/A 7.419±0.80 25.891±4.43 1.551±0.47 3.719±0.91 2.851±0.84 5.466±1.46 N/A 9.758±4.45 1.763±0.37 1.162±0.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093P CIL_00093P_0002 VISTA 19:55176600-55777537
CIL_0006OU CIL_0006OU_0002 CGP 19:55316351-55933654
CIL_0007PE CIL_0007PE_0002 UCNEbase 19:55350713-56087023
CIL_0006OX CIL_0006OX_0002 CGP 19:55741810-56320822

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IEA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001568 IEA blood vessel development
GO:0003682 IDA chromatin binding
GO:0003700 IBA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0005977 IMP glycogen metabolic process
GO:0006006 IMP glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0007050 IEA cell cycle arrest
GO:0008013 IPI beta-catenin binding
GO:0008134 IEA transcription factor binding
GO:0008283 IEA cell proliferation
GO:0009267 IMP cellular response to starvation
GO:0009749 IMP response to glucose
GO:0009791 IMP post-embryonic development
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010909 IEA positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 IMP oligodendrocyte development
GO:0016055 IGI Wnt signaling pathway
GO:0019901 IEA protein kinase binding
GO:0021915 IGI neural tube development
GO:0021983 IMP pituitary gland development
GO:0030282 IGI bone mineralization
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030538 IGI embryonic genitalia morphogenesis
GO:0031641 IMP regulation of myelination
GO:0032024 IMP positive regulation of insulin secretion
GO:0032092 IEA positive regulation of protein binding
GO:0032252 IMP secretory granule localization
GO:0032350 IEA regulation of hormone metabolic process
GO:0032993 IEA protein-DNA complex
GO:0035019 IMP somatic stem cell maintenance
GO:0035257 IEA nuclear hormone receptor binding
GO:0035264 IMP multicellular organism growth
GO:0035411 IDA catenin import into nucleus
GO:0040037 IMP negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IGI odontogenesis of dentin-containing tooth
GO:0042593 IEA glucose homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0043570 IEA maintenance of DNA repeat elements
GO:0043588 IGI skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044334 IEA canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 IEA gamma-catenin binding
GO:0045444 IEA fat cell differentiation
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045722 IMP positive regulation of gluconeogenesis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046621 IMP negative regulation of organ growth
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0046889 IMP positive regulation of lipid biosynthetic process
GO:0048557 IGI embryonic digestive tract morphogenesis
GO:0048619 IGI embryonic hindgut morphogenesis
GO:0048625 IMP myoblast fate commitment
GO:0048641 IMP regulation of skeletal muscle tissue development
GO:0048660 IEA regulation of smooth muscle cell proliferation
GO:0048713 IMP regulation of oligodendrocyte differentiation
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060325 IGI face morphogenesis
GO:0061178 IMP regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070016 IEA armadillo repeat domain binding
GO:0070369 IEA beta-catenin-TCF7L2 complex
GO:0071664 IDA catenin-TCF7L2 complex
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1901142 IMP insulin metabolic process
GO:2000675 IEA negative regulation of type B pancreatic cell apoptotic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004415 tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) protein_coding Danio_rerio
ENSG00000148737 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) protein_coding Homo_sapiens

Loading