C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000148737 TCF7L2 9606 + 10:112950250-113167678 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000277945 TCF7L2-010 113146072-113165632 protein_coding
  ENST00000346198 TCF7L2-002 112950916-113141316 protein_coding
  ENST00000349937 TCF7L2-004 112950452-113146103 protein_coding
  ENST00000352065 TCF7L2-201 112950250-113167678 protein_coding
  ENST00000355717 TCF7L2-202 112950250-113167678 protein_coding
  ENST00000355995 TCF7L2-203 112950250-113167678 protein_coding
  ENST00000369386 TCF7L2-006 113151083-113166324 protein_coding
  ENST00000369389 TCF7L2-007 113143920-113165656 protein_coding
  ENST00000369395 TCF7L2-001 112950672-113146103 protein_coding
  ENST00000369397 TCF7L2-003 112950452-113167678 protein_coding
  ENST00000466338 TCF7L2-011 113151771-113166309 processed_transcript
  ENST00000470254 TCF7L2-013 113151831-113165940 nonsense_mediated_decay
  ENST00000471569 TCF7L2-005 113157773-113165587 processed_transcript
  ENST00000476887 TCF7L2-009 113158037-113166160 processed_transcript
  ENST00000480888 TCF7L2-008 113152414-113165961 processed_transcript
  ENST00000494353 TCF7L2-012 113161231-113165681 processed_transcript
  ENST00000534894 TCF7L2-204 112950250-113167678 protein_coding
  ENST00000536810 TCF7L2-205 112950250-113167678 protein_coding
  ENST00000538897 TCF7L2-206 112950250-113167678 protein_coding
  ENST00000542695 TCF7L2-207 112950250-113167678 protein_coding
  ENST00000543371 TCF7L2-208 112950250-113167678 protein_coding
  ENST00000545257 TCF7L2-209 112950250-113167678 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000277945ENST00000349937ENST00000352065ENST00000355995ENST00000369389ENST00000369397ENST00000466338ENST00000471569ENST00000536810ENST00000538897ENST00000543371ENST00000545257
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000277945 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.012±0.00 N/A N/A
ENST00000349937 N/A N/A 1.744±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000352065 N/A N/A N/A 0.183±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000355995 N/A N/A N/A N/A N/A N/A 1.323±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000369389 N/A N/A 4.991±0.00 N/A N/A N/A N/A N/A 3.133±0.00 N/A 1.127±0.00 N/A N/A 1.776±0.00
ENST00000369397 12.773±0.00 2.981±0.00 N/A 2.839±0.00 7.548±0.00 10.156±0.00 N/A N/A 1.501±0.00 N/A N/A 5.702±0.75 3.162±1.28 12.591±0.00
ENST00000466338 N/A N/A N/A N/A 2.674±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000471569 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.489±0.00 N/A N/A N/A
ENST00000536810 N/A N/A N/A N/A N/A N/A N/A 0.855±0.00 N/A N/A N/A N/A N/A N/A
ENST00000538897 4.654±0.00 N/A 0.841±0.00 N/A 0.628±0.00 N/A N/A N/A N/A N/A N/A 2.031±0.00 2.658±1.23 N/A
ENST00000543371 N/A N/A N/A N/A 1.460±0.00 1.340±0.00 N/A N/A 1.578±1.08 1.253±0.00 N/A 2.786±0.60 4.434±2.32 N/A
ENST00000545257 N/A N/A N/A 0.126±0.00 N/A N/A N/A N/A N/A N/A N/A 1.143±0.00 N/A 0.674±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OU CIL_0006OU_0001 CGP 10:112446998-113167678
CIL_0007PE CIL_0007PE_0001 UCNEbase 10:112490627-113337047
CIL_0006OX CIL_0006OX_0001 CGP 10:112950250-113589602

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001568 IMP blood vessel development
GO:0003682 IBA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IBA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005977 IEA glycogen metabolic process
GO:0006006 IEA glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007050 IMP cell cycle arrest
GO:0007420 IBA brain development
GO:0008013 IEA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008283 IMP cell proliferation
GO:0009267 IEA cellular response to starvation
GO:0009749 ISS response to glucose
GO:0009791 IEA post-embryonic development
GO:0010867 IEA positive regulation of triglyceride biosynthetic process
GO:0010909 IMP positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 IEA oligodendrocyte development
GO:0016055 IEA Wnt signaling pathway
GO:0019901 IPI protein kinase binding
GO:0021915 IEA neural tube development
GO:0021983 IEA pituitary gland development
GO:0030282 IEA bone mineralization
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030538 IEA embryonic genitalia morphogenesis
GO:0031016 TAS pancreas development
GO:0031641 IEA regulation of myelination
GO:0032024 IDA positive regulation of insulin secretion
GO:0032092 IDA positive regulation of protein binding
GO:0032252 IEA secretory granule localization
GO:0032350 IDA regulation of hormone metabolic process
GO:0032993 IDA protein-DNA complex
GO:0035019 IEA somatic stem cell maintenance
GO:0035257 IPI nuclear hormone receptor binding
GO:0035264 IEA multicellular organism growth
GO:0035411 IEA catenin import into nucleus
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042593 IDA glucose homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0043570 IMP maintenance of DNA repeat elements
GO:0043588 IEA skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044334 IMP canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 IPI gamma-catenin binding
GO:0045444 IDA fat cell differentiation
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046621 IEA negative regulation of organ growth
GO:0046827 IMP positive regulation of protein export from nucleus
GO:0046889 IEA positive regulation of lipid biosynthetic process
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048619 IEA embryonic hindgut morphogenesis
GO:0048625 IDA myoblast fate commitment
GO:0048641 IEA regulation of skeletal muscle tissue development
GO:0048660 IMP regulation of smooth muscle cell proliferation
GO:0048699 IBA generation of neurons
GO:0048713 IEA regulation of oligodendrocyte differentiation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060325 IEA face morphogenesis
GO:0061178 IEA regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070016 IPI armadillo repeat domain binding
GO:0070369 IDA beta-catenin-TCF7L2 complex
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:1901142 IEA insulin metabolic process
GO:2000675 IDA negative regulation of type B pancreatic cell apoptotic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004415 tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) protein_coding Danio_rerio
ENSMUSG00000024985 Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box protein_coding Mus_musculus

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