C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor 7 like 2, T cell specific, HMG box
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000111657 Tcf7l2-202 ENSMUSG00000024985 10090 + 19:55741810-55933654 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderHeartLiverMusclePlacentaENSMUST00000111657
Transcript ID Bladder Heart Liver Muscle Placenta
ENSMUST00000111657 1.528±0.00 0.821±0.17 3.680±0.00 0.242±0.08 1.073±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093P CIL_00093P_0002 VISTA 19:55176600-55777537
CIL_0006OU CIL_0006OU_0002 CGP 19:55316351-55933654
CIL_0007PE CIL_0007PE_0002 UCNEbase 19:55350713-56087023
CIL_0006OX CIL_0006OX_0002 CGP 19:55741810-56320822

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IEA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001568 IEA blood vessel development
GO:0003682 IDA chromatin binding
GO:0003700 IBA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005977 IMP glycogen metabolic process
GO:0006006 IMP glucose metabolic process
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007050 IEA cell cycle arrest
GO:0008013 IPI beta-catenin binding
GO:0008134 IEA transcription factor binding
GO:0008283 IEA cell proliferation
GO:0009267 IMP cellular response to starvation
GO:0009791 IMP post-embryonic development
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010909 IEA positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 IMP oligodendrocyte development
GO:0016055 IGI Wnt signaling pathway
GO:0019901 IEA protein kinase binding
GO:0021915 IGI neural tube development
GO:0021983 IMP pituitary gland development
GO:0030282 IGI bone mineralization
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030538 IGI embryonic genitalia morphogenesis
GO:0031641 IMP regulation of myelination
GO:0032024 IEA positive regulation of insulin secretion
GO:0032092 IEA positive regulation of protein binding
GO:0032252 IMP secretory granule localization
GO:0032350 IEA regulation of hormone metabolic process
GO:0032993 IEA protein-DNA complex
GO:0035019 IMP somatic stem cell maintenance
GO:0035257 IEA nuclear hormone receptor binding
GO:0035264 IMP multicellular organism growth
GO:0035411 IDA catenin import into nucleus
GO:0040037 IMP negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IGI odontogenesis of dentin-containing tooth
GO:0042593 IEA glucose homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0043570 IEA maintenance of DNA repeat elements
GO:0043588 IGI skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044334 IEA canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 IEA gamma-catenin binding
GO:0045444 IEA fat cell differentiation
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045722 IMP positive regulation of gluconeogenesis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046621 IMP negative regulation of organ growth
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0046889 IMP positive regulation of lipid biosynthetic process
GO:0048557 IGI embryonic digestive tract morphogenesis
GO:0048619 IGI embryonic hindgut morphogenesis
GO:0048625 IMP myoblast fate commitment
GO:0048641 IMP regulation of skeletal muscle tissue development
GO:0048660 IEA regulation of smooth muscle cell proliferation
GO:0048713 IMP regulation of oligodendrocyte differentiation
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060325 IGI face morphogenesis
GO:0061178 IMP regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070016 IEA armadillo repeat domain binding
GO:0070369 IEA beta-catenin-TCF7L2 complex
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1901142 IMP insulin metabolic process
GO:2000675 IEA negative regulation of type B pancreatic cell apoptotic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000125046 tcf7l2-008 protein_coding Danio_rerio 0 1336
ENSDART00000031408 tcf7l2-009 protein_coding Danio_rerio 0 1279
ENSDART00000121527 tcf7l2-201 protein_coding Danio_rerio 0 1256
ENSDART00000153068 tcf7l2-001 protein_coding Danio_rerio 0 1240
ENSDART00000005562 tcf7l2-007 protein_coding Danio_rerio 0 1182
ENSDART00000122972 tcf7l2-006 protein_coding Danio_rerio 0 782
ENSDART00000009237 tcf7l2-002 protein_coding Danio_rerio 0 782
ENSDART00000128703 tcf7l2-003 processed_transcript Danio_rerio 0 409
ENSDART00000133854 tcf7l2-005 protein_coding Danio_rerio 0 399
ENSDART00000145967 tcf7l2-004 protein_coding Danio_rerio 0 313
ENST00000277945 TCF7L2-010 protein_coding Homo_sapiens 0 558
ENST00000346198 TCF7L2-002 protein_coding Homo_sapiens 0 405
ENST00000349937 TCF7L2-004 protein_coding Homo_sapiens 0 924
ENST00000352065 TCF7L2-201 protein_coding Homo_sapiens 0 4549
ENST00000355717 TCF7L2-202 protein_coding Homo_sapiens 0 2135
ENST00000355995 TCF7L2-203 protein_coding Homo_sapiens 0 3450
ENST00000369386 TCF7L2-006 protein_coding Homo_sapiens 0 907
ENST00000369389 TCF7L2-007 protein_coding Homo_sapiens 0 811
ENST00000369395 TCF7L2-001 protein_coding Homo_sapiens 0 804
ENST00000369397 TCF7L2-003 protein_coding Homo_sapiens 0 4373
ENST00000466338 TCF7L2-011 processed_transcript Homo_sapiens 0 870
ENST00000470254 TCF7L2-013 nonsense_mediated_decay Homo_sapiens 0 472
ENST00000476887 TCF7L2-009 processed_transcript Homo_sapiens 0 628
ENST00000494353 TCF7L2-012 processed_transcript Homo_sapiens 0 209
ENST00000534894 TCF7L2-204 protein_coding Homo_sapiens 0 2135
ENST00000536810 TCF7L2-205 protein_coding Homo_sapiens 0 2322
ENST00000538897 TCF7L2-206 protein_coding Homo_sapiens 0 2139
ENST00000542695 TCF7L2-207 protein_coding Homo_sapiens 0 3118
ENST00000543371 TCF7L2-208 protein_coding Homo_sapiens 0 2146
ENST00000545257 TCF7L2-209 protein_coding Homo_sapiens 0 2473

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