C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026104 Stat1 10090 + 1:52119440-52161865 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000070968 Stat1-001 52119455-52161865 protein_coding
  ENSMUST00000185743 Stat1-005 52119572-52137852 retained_intron
  ENSMUST00000186057 Stat1-009 52119624-52160730 protein_coding
  ENSMUST00000186186 Stat1-013 52119559-52120394 retained_intron
  ENSMUST00000186574 Stat1-004 52119440-52155412 protein_coding
  ENSMUST00000186857 Stat1-006 52119492-52161007 protein_coding
  ENSMUST00000188681 Stat1-012 52119498-52132633 protein_coding
  ENSMUST00000189075 Stat1-014 52150104-52152399 retained_intron
  ENSMUST00000189244 Stat1-010 52150258-52161863 protein_coding
  ENSMUST00000189336 Stat1-015 52152253-52159560 nonsense_mediated_decay
  ENSMUST00000189347 Stat1-008 52119549-52155331 protein_coding
  ENSMUST00000191435 Stat1-007 52119490-52155412 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000070968ENSMUST00000186057ENSMUST00000186574ENSMUST00000186857ENSMUST00000188681ENSMUST00000189336ENSMUST00000189347
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000070968 N/A 6.087±0.02 N/A 0.315±0.00 N/A 1.453±0.11 N/A N/A N/A N/A N/A 4.014±0.28 N/A
ENSMUST00000186057 N/A N/A N/A 0.828±0.00 N/A N/A N/A N/A N/A N/A 1.240±0.33 5.694±0.02 4.169±1.88
ENSMUST00000186574 10.020±0.53 19.923±2.61 9.577±3.12 0.959±0.03 18.289±3.21 4.050±0.64 2.831±0.83 6.102±0.88 6.635±2.84 5.916±1.54 0.959±0.40 9.680±2.46 6.015±1.88
ENSMUST00000186857 15.913±0.96 12.288±1.37 17.768±3.64 1.499±0.58 21.917±2.78 3.706±1.15 5.806±0.31 8.203±1.07 6.921±2.12 14.219±1.47 2.504±0.76 10.669±3.24 7.128±2.88
ENSMUST00000188681 19.708±1.72 38.041±3.71 N/A N/A 33.515±6.60 7.608±1.65 N/A 6.087±0.00 10.428±2.72 16.547±2.12 N/A 25.939±9.25 N/A
ENSMUST00000189336 N/A N/A N/A 3.192±0.00 N/A N/A N/A N/A N/A N/A N/A 12.558±0.00 7.644±0.00
ENSMUST00000189347 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.277±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AM CIL_0009AM_0002 VISTA 1:51779533-52380137
CIL_0002AL CIL_0002AL_0002 CGP 1:51987148-52161865
CIL_0002SJ CIL_0002SJ_0003 CGP 1:52119440-52233232

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983 IEA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0003677 IEA DNA binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0006351 IMP transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007259 IEA JAK-STAT cascade
GO:0007584 IEA response to nutrient
GO:0008015 IEA blood circulation
GO:0008284 IEA positive regulation of cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009617 IDA response to bacterium
GO:0014070 IEA response to organic cyclic compound
GO:0016525 IEA negative regulation of angiogenesis
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019899 IEA enzyme binding
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032496 IDA response to lipopolysaccharide
GO:0032869 IEA cellular response to insulin stimulus
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0034097 IEA response to cytokine
GO:0034240 IMP negative regulation of macrophage fusion
GO:0035458 IEA cellular response to interferon-beta
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 IDA response to exogenous dsRNA
GO:0043434 IEA response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051591 IEA response to cAMP
GO:0061326 IEA renal tubule development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006266 stat1a signal transduction and activation of transcription 1a protein_coding Danio_rerio
ENSDARG00000076182 stat1b signal transducer and activator of transcription 1b protein_coding Danio_rerio
ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa protein_coding Homo_sapiens

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